Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo +11 more
wiley +1 more source
Addendum: Testing structural balance theories in heterogeneous signed networks
Anna Gallo +4 more
doaj +1 more source
Plasticizer-Dependent Vulcanization, Crosslinking, and Magneto-Viscoelasticity of Natural Rubber-Based Magnetorheological Elastomers. [PDF]
Fan L +7 more
europepmc +1 more source
Disentangling the Genetic Relationship Between Sleep and Epilepsy
ABSTRACT Objective A bidirectional relationship between sleep and epilepsy is well recognised, yet the biological mechanisms linking them remain poorly understood. Both have a genetic basis, with genome‐wide association studies (GWAS) capturing polygenic contributions.
Khang N. Le +9 more
wiley +1 more source
A Dynamic Succession-Based Life-Cycle Simulation Model for Projecting Carbon Source-Sink Transitions in Urban Plant Communities. [PDF]
Liuyang X, Lu J, Cao Y.
europepmc +1 more source
Objective Our objective was to describe the social networks of Black individuals with rheumatic and musculoskeletal conditions and understand the clustering of health‐related behaviors to inform future community‐based, peer‐led interventions. Methods We used an adapted Personal Network Survey for Clinical Research (PERSNET) to map the personal social ...
Taussia Boadi +27 more
wiley +1 more source
Objective High body mass index (BMI≥27 kg/m2) and aberrant gait biomechanics are primary risk factors for knee osteoarthritis (KOA), yet the specific loading patterns linked to clinical disease features remain unclear. Unsupervised machine learning (ML) was used to identify vertical ground reaction force (vGRF) waveform modes of variation and ...
Ashley N. Buck +10 more
wiley +1 more source
Force-Balance Model and Stable Operating-Point Regulation of a Prestretched Repulsive Electromagnetic Elastomer Artificial Muscle. [PDF]
Wang J, Cao S, Wang Z, Zhang H, Wang Y.
europepmc +1 more source
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur +5 more
wiley +1 more source
Association between injury severity and recovery of objective functional measures following adolescent lateral ankle sprain: a secondary cohort analysis. [PDF]
Meškauskas M +6 more
europepmc +1 more source

