Results 61 to 70 of about 5,441,128 (292)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Spreading and Structural Balance on Signed Networks

SIAM Journal on Applied Dynamical Systems
Two competing types of interactions often play an important part in shaping system behavior, such as activatory or inhibitory functions in biological systems. Hence, signed networks, where each connection can be either positive or negative, have become popular models over recent years.
Yu Tian, Renaud Lambiotte
openaire   +4 more sources

Astheno–Kähler and Balanced Structures on Fibrations [PDF]

International Mathematics Research Notices, 2017
AbstractWe study the existence of three classes of Hermitian metrics on certain types of compact complex manifolds. More precisely, we consider balanced, strong Kähler with torsion (SKT), and astheno-Kähler metrics. We prove that the twistor spaces of compact hyperkähler and negative quaternionic-Kähler manifolds do not admit astheno-Kähler metrics ...
Anna Fino, Gueo Grantcharov, Luigi Vezzoni   +2 more
openaire   +3 more sources

An econometric model of the balance of payments of Venezuela [PDF]

, 1989
PhDThe fundamental purpose of this study is to build an econometric model of the Venezuelan Economy to concentrate primarely on the following: first, to analyse the effects of monetary, fiscal and external disturbances on expenditures, prices and on ...
Escalante, Alexander Jose Guerrero
core   +2 more sources

Structural balance of Kazakhstan's regional hotel business

Хабаршысы. Экономика сериясы
Hotel-business development in Kazakhstan is characterized not only by wide regional gaps but also by unequal combinations of infrastructure, demand, economic conversion, quality structure and labour use.
A. Rakhmetulina, Zh. Rakhmetulina, A. Omurzakov, T. Abylaikhanova   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural Balance as an Indicator of the Assessment of Fiscal Policy in the Euro Area Countries

Acta Universitatis Lodziensis. Folia Oeconomica, 2016
The main aim of this article is to submit an idea of the structural balance within the euro area fiscal surveillance framework, characterising its main methodological aspects and analysing the level of structural balance in the euro area countries in the
Juliusz Giżyński
doaj   +1 more source