Results 61 to 70 of about 2,365 (218)

Optimal forecasts in the presence of structural breaks [PDF]

Journal of Econometrics, 2011
This paper considers the problem of forecasting under continuous and discrete structural breaks and proposes weighting observations to obtain optimal forecasts in the MSFE sense. We derive optimal weights for continuous and discrete break processes. Under continuous breaks, our approach recovers exponential smoothing weights.
M Hashem Pesaran, Andreas Pick, Mikhail Pranovich   +2 more
openaire   +2 more sources

A Time Series Analysis for Supply Response Scenario of Food Grains in Bangladesh: The Quest of Structural Changes

Journal of Agriculture, Food and Environment, 2020
Using time-series data, we examined the structural stability and supply response scenario of cereal food production for the last five decades.
Mohammad Ariful Islam
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Ice breaking in GPCR structural biology [PDF]

Acta Pharmacologica Sinica, 2012
G-protein-coupled receptors (GPCRs) are one of the most challenging targets in structural biology. To successfully solve a high-resolution GPCR structure, several experimental obstacles must be overcome, including expression, extraction, purification, and crystallization.
Qiang, Zhao, Bei-li, Wu
openaire   +2 more sources

El Teorema del Límite Central Funcional con algunas aplicaciones a raíces unitarias con cambios estructurales

Economía, 2013
Hoy en día es una práctica estándar de trabajo empírico la aplicación de diferentes estadísticos de contraste de raíz unitaria. A pesar de ser un aspecto práctico, estos estadísticos poseen distribuciones complejas y no estándar que dependen de ...
Juan Carlos Aquino, Gabriel Rodríguez
doaj  

The Effect of Inflation on Economic Growth in Iran with Special Emphasis on Uncertainty [PDF]

پژوهشهای اقتصادی, 2011
Hyper inflation rates impose direct and indirect costs upon society. It has undesirable consequences that are caused by inflation uncertainty. In this regard, the following questions are raised: How do inflation rate and its uncertainty affect economic ...
Khosro Piraee, Bahareh Dadvar
doaj  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source