Results 71 to 80 of about 1,643,550 (313)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Revista de Economia Contemporânea, 2020 In the period 2014-2018, South American economies experienced a low growth rate in a historical perspective and compared with other developing regions.
Martín Abeles, Martín Cherkasky
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Innovation, demand and structural change in Europe. [PDF]
The model and the empirical test developed in this paper address the determinants of structural change for six major European economies from 1995 to 2007.
Matteo Lucchese
core
Desindustrialização: conceituação, causas, efeitos e o caso brasileiro
Brazilian Journal of Political Economy, 2010 De-Industrialization: concept, causes, effects and the Brazilian case. This article aims to do a theoretical discussion about the term "de-industrialization" and its relationship with other concepts as "primarization" of exports and "Dutch disease ...
José Luis Oreiro, Carmem A. Feijó
doaj +1 more source
Environmental Research Letters, 2020 The Yellow River Delta (YRD) has been experiencing substantial climatic, hydrological, and anthropogenic stresses, and a sound understanding of the regime shift in its hydroclimate–vegetation system is of fundamental importance for maintaining the health
Beibei Niu +6 more
doaj +1 more source