Results 91 to 100 of about 1,643,550 (313)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
The dynamics of structural change under risk influence [PDF]
The paper is concerned with structural change in the growth process and the role of uncertainty. Uncertainty is conceived as the means of removing the obstacles of growth through the activation of knightian entrepreneurship. A dynamic stochastic model of
Panayiotis Petrakis, Stylianos Kotsios
core
Dijitaleşme Çağında Robotların ve Robotik Süreç Otomasyonunun Ekonomik Etkileri
Ekonomi, Politika & Finans Araştırmaları DergisiTeknolojik değişme, ekonomik büyüme sürecinin arkasındaki temel güçtür. Robotik süreç otomasyonu ve robotlar, daha önce ortaya çıkan buhar teknolojisinin ve elektrik enerjisinin yarattığı etkiler kadar ekonomik büyüme sürecine önemli katkı yapabilecek ...
Metin Recep Zafer, Furkan Börü
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Emerging Patterns of Manufacturing Structural Change [PDF]
In the past, research on changes in relative importance among broad three sectors— agriculture, industry, and service—showed general patterns of a country’s structural transformation along with economic development.
Nobuya Haraguchi, Gorazd Rezonja
core
The Impact of Innovation Policy on the Sectoral Structure of the Estonian Economy
Eesti Majanduspoliitilised Väitlused, 2009 The current global economic crisis has increased the awareness of the role of knowledge-based economy in raising international competitiveness. For contributing to faster economic restructuring, knowing the quantitative effects of innovation policy ...
Laura Ruud
doaj +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source