Results 121 to 130 of about 2,083,635 (328)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Wear Behavior of Ti-xNb Biomedical Alloys by Ball Cratering [PDF]

Materials Research
Ti alloys have been developing through the years, aiming the biomedical application since it has suitable properties. Among Ti alloys, the Ti-Nb systems are a pronounced group to biomedical applications due to its low elastic modulus, good corrosion ...
Felype N. de Mattos, Pedro A. B. Kuroda, Mariana C. Rossi, Conrado R. M. Afonso   +3 more
doaj   +1 more source

Synthesis and structural characterization of benzene-1,3-disulfonamide-containing 11- to 13-membered heterocycles via double Mitsunobu annulation [PDF]

, 2023
Kyosuke Kaneda, Takato Koideya, Ryuji Toshima, Yoshiki Konno, Takehiro Yamagishi   +4 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Extraction, Purification, Structural Characteristics, Biological Activities, and Applications of Polysaccharides from Gastrodia elata: A Review

Molecules
Gastrodia elata Blume is a well-known medicinal and edible plant in China, celebrated for its extensive history in traditional medicine and functional food applications. Among its key bioactive components, polysaccharides have drawn significant attention
Yan Yang, Yonglin Hai, Yongcheng Yang, Rouyuan Wen, Le Wang, Yan Qian, Jiaxian Zhang, Yongguo Li, Zhilong Shi, Haizhu Zhang   +9 more
doaj   +1 more source

Structural characterization and bioactivities of a polysaccharide from the stalk residue of Pleurotus eryngii [PDF]

, 2020
Heng‐Guang Zheng, Junchen Chen, Minjie Weng, Ijaz Ahmad, Chun-Quan ZHOU   +4 more
openalex   +1 more source

Optimization of hot-press process and structural characterization of PF Camellia oleifera cake adhesive [PDF]

, 2022
Xiao Hu, Rui Zeng, Yuyuan Li, Jinghua Zhou, Xi Li, Yong Wang, Xiang Li, Dong Wang   +7 more
openalex   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Structural Characterization of Foxtail Millet (Setaria italica) Polysaccharides and Evaluation of Its Antioxidant and Immunostimulatory Activities

Antioxidants
A water-soluble polysaccharide from foxtail millet (FM-D1) was isolated and purified through gradient ethanol precipitation and column chromatography.
Haiying Zhang, Chengyu Peng, Wei Zhang, Huatao Liu, Xiaodong Liu, Changqing Sun, Xiaoning Cao   +6 more
doaj   +1 more source