Results 11 to 20 of about 8,575,116 (341)

Structural Modification and Biological Activity of Polysaccharides

Molecules, 2023
Natural polysaccharides are macromolecular substances with a wide range of biological activities. The structural modification of polysaccharides by chemical means can enhance their biological activity.
Ting Zhao, Min Yang, Lina Ma, Xinglong Liu, Qiteng Ding, Guodong Chai, Yang Lu, Hewei Wei, Shuai Zhang, Chuanbo Ding   +9 more
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Intelligent Protein Design and Molecular Characterization Techniques: A Comprehensive Review

Molecules, 2023
In recent years, the widespread application of artificial intelligence algorithms in protein structure, function prediction, and de novo protein design has significantly accelerated the process of intelligent protein design and led to many noteworthy ...
Jingjing Wang, Chang Chen, Ge Yao, Junjie Ding, Liangliang Wang, Hui Jiang   +5 more
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Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10

Nature Communications, 2020
Human ubiquitin E3 ligase E6AP contains a Zn-binding AZUL domain. Here the authors identify and name RAZUL, a domain in proteasome substrate receptor hRpn10 that binds AZUL, recruiting E6AP to proteasomes, and they present the NMR structure of the RAZUL ...
Gwen R. Buel, Xiang Chen, Raj Chari, Maura J. O’Neill, Danielle L. Ebelle, Conor Jenkins, Vinidhra Sridharan, Sergey G. Tarasov, Nadya I. Tarasova, Thorkell Andresson, Kylie J. Walters   +10 more
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Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma

Nature Communications, 2021
Rpn13 is a substrate receptor of the 26S proteasome and an anti-cancer drug target. Here, the authors identify and characterize XL5, a lead compound that binds to the N-terminal Pru domain of human Rpn13 (hRpn13), solve the NMR structure of XL5-ligated ...
Xiuxiu Lu, Venkata R. Sabbasani, Vasty Osei-Amponsa, Christine N. Evans, Julianna C. King, Sergey G. Tarasov, Marzena Dyba, Sudipto Das, King C. Chan, Charles D. Schwieters, Sulbha Choudhari, Caroline Fromont, Yongmei Zhao, Bao Tran, Xiang Chen, Hiroshi Matsuo, Thorkell Andresson, Raj Chari, Rolf E. Swenson, Nadya I. Tarasova, Kylie J. Walters   +20 more
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Systematic Comparison of Structural Characterization of Polysaccharides from Ziziphus Jujuba cv. Muzao

Molecules, 2023
To investigate the structural information differences of Ziziphus Jujuba cv. Muzao polysaccharides, ten samples were successfully extracted from aqueous and alkaline solutions, prepared via DEAE-Sepharose Fast Flow through different eluents and Sephacryl
Xiaolong Ji, Shuli Zhang, Xueyuan Jin, Chuanxue Yin, Yang Zhang, Xudan Guo, Ximeng Lin   +6 more
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Characterizing polygonality in biological structures [PDF]

Physical Review E, 2006
Several systems involve spatial arrangements of elements such as molecules or cells, the characterization of which bears important implications to biological and physical investigations. Traditional approaches to quantify spatial order and regularity have relied on nearest neighbor distances or the number of sides of cells.
Costa, Luciano da Fontoura, Rocha, Fernando, de Lima, Silene Araujo   +2 more
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Structural Flyby Characterization of Nanoporosity [PDF]

, 2004
Recently, Ferreira da Silva et al. [3] have performed a gradient pattern analysis of a canonical sample set (CSS) of scanning force microscopy (SFM) images of p-Si.
Andersen, Canham, Ferreira da Silva, Ferreira da Silva, Lockwood, Mammana, Ramos, Rosa, Rosa   +8 more
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A combined evolutionary and structural approach to disclose the primary structural determinants essential for proneurotrophins biological functions

Computational and Structural Biotechnology Journal, 2021
The neurotrophins, i.e., Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin 3 (NT3) and Neurotrophin 4 (NT4), are known to play a range of crucial functions in the developing and adult peripheral and central nervous systems.
S. Covaceuszach, L.Y. Peche, P.V. Konarev, D. Lamba   +3 more
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A Structural Characterization of Human SCO2 [PDF]

Structure, 2007
Human Sco2 is a mitochondrial membrane-bound protein involved in copper supply for the assembly of cytochrome c oxidase in eukaryotes. Its precise action is not yet understood. We report here a structural and dynamic characterization by NMR of the apo and copper(I) forms of the soluble fragment.
BANCI, LUCIA, BERTINI, IVANO, CIOFI BAFFONI, SIMONE, I. P. Gerothanassis, I. Leontari, M. Martinelli, S. Wang   +6 more
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Processing and characterization of CaTiO3 perovskite ceramics [PDF]

Processing and Application of Ceramics, 2014
Calcium titanate (CaTiO3) ceramics with perovskite structure were produced by solid state reaction. Calcium carbonate (CaCO3) and titanium dioxide (TiO2) were mixed (in molar ratios 1/1 and 3/2), and the obtained mixtures were calcined at 1150 °C in ...
Guilherme Gralik, Alessandra E. Thomsen, Cristian A. Moraes, Fabiano Raupp-Pereira, Dachamir Hotza   +4 more
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