Results 71 to 80 of about 340,966 (303)
Empirical validation of ProteinMPNN’s efficiency in enhancing protein fitness
Frontiers in GeneticsIntroduction: Protein engineering, which aims to improve the properties and functions of proteins, holds great research significance and application value.
Tianshu Wang +20 more
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Underwater image matching by incorporating structural constraints
International Journal of Advanced Robotic Systems, 2017 Underwater robot plays an important role in underwater perception and manipulation tasks. Vision information processing is essential for the intelligent perception of an underwater robot, in which image matching is a fundamental topic.
Xu Yang +6 more
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Stability constraints on large-scale structural brain networks
Frontiers in Computational Neuroscience, 2013 Stability is an important dynamical property of complex systems and underpins a broad range of coherent self-organized behaviour. Based on evidence that some neurological disorders correspond to linear instabilities,we hypothesize that stability ...
Richard T. Gray +3 more
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ON CONSTRAINTS AND DIVIDING IN TERNARY HOMOGENEOUS STRUCTURES [PDF]
The Journal of Symbolic Logic, 2018 AbstractLet ${\cal M}$ be ternary, homogeneous and simple. We prove that if ${\cal M}$ is finitely constrained, then it is supersimple with finite SU-rank and dependence is k-trivial for some k < ω and for finite sets of real elements. Now suppose that, in addition, ${\cal M}$ is supersimple with SU-rank 1.
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Structural Modelling of Financial Constraints on Investment: Where Do We Stand? [PDF]
This paper surveys issues with respect to the structural modelling of econometric tests of investment facing financial constraints, to their link with firms data and asset prices, and to their consequences for macroeconomic modelling. The key issue is to
Jean-Bernard Chatelain
core
Structural studies by cryo-electron tomography of two initiation complexes of the immune system: C1-IgG6 and NAIP5-NLRC4 [PDF]
, 2015 Complement activation by antibodies bound to pathogens, tumors, and self antigens is a critical feature of natural immune defense, a number of disease processes, and immunotherapies.
Sub Crystal and Structural Chemistry +2 more
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Вестник университета, 2020 The theoretical and economic study of various aspects of the impact of external restrictions on the Russian economy in recent years has become one of the actively developing areas of scientific research.
V. M. Vazagov, M. B. Miroshnichenko
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The Left-Left Constraint: A structural constraint on adjuncts
, 2022 Left-hand adjuncts of left-headed (= head-initial) phrases are constrained in a particular way. The constraint, which is absent for adjuncts of head-final phrases, is this. The head of the adjunct must be in the absolute phrase-final position. Anything that follows the head disqualifies the phrase as an adjunct. The effect of this head-final-constraint
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