Results 51 to 60 of about 4,792,487 (297)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
On the Reification of Global Constraints [PDF]
, 2012 We introduce a simple idea for deriving reified global constraints in a systematic way. It is based on the observation that most global constraints can be reformulated as a conjunction of pure functional dependency constraints together with a ...
Flener, Pierre, +7 more
core +1 more source
SystemsAustralia’s National Housing Accord aims to deliver 1.2 million new dwellings between mid-2024 and mid-2029, representing 240,000 annual completions—a 37% increase above the 2024 baseline of 175,000.
Gavin Melles
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
GERMANY’S LABOUR SHORTAGE: BETWEEN STRUCTURAL PRESSURE AND UNCERTAIN HORIZONS [PDF]
Global Economic ObserverGermany is currently facing a profound labour shortage that transcends sectoral boundaries and reflects deeper demographic and structural transformations. Following a brief post-pandemic rebound, the German economy has entered a phase of stagnation and
ANA-CRISTINA BÂLGĂR
doaj
AgricultureThis study examines how structural constraints and institutional support are associated with the configuration of agricultural production systems in Durango, Mexico.
Omar Alfonso Rivera-Hernández +6 more
doaj +1 more source
Structural decompositions for problems with global constraints [PDF]
Constraints, 2015 The final publication is available at Springer via http://dx.doi.org/10.1007/s10601-015-9181 ...
openaire +4 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
(De)Constructing Conflict: A Focused Review of War and Peace Journalism [PDF]
Conflict & Communication Online, 2006 This overview of the media and conflict literature and case study of media coverage of peace offers a framework and guidance for peace journalism. Many studies show media rarely report conflict neutrally.
Susan Dente Ross
doaj
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source