Results 71 to 80 of about 7,721,766 (241)

Experience‐Dependent Reorganization of Hippocampal CA3 Neuronal Ensembles Associates With Memory Generalization

Advanced Science, EarlyView.
Mice can transfer the learned rule of spatial working memory to guide similar but novel tasks. Hippocampal CA3 populational activity dynamically reorganize during memory generalization, shifting from task‐specific to generalized coding over testing days. Sparse yet redundant neural representations of CA3 enable rule transfer and cognitive map formation,
Da Song, Zilu Zhu, Yujun Deng, Yujie Song, Hui Li, Junjun Ni, Zhenzhen Quan, Yan Yan, Hong Qing   +8 more
wiley   +1 more source

Early grey matter changes in structural covariance networks in Huntington's disease

NeuroImage: Clinical, 2016
Background: Progressive subcortical changes are known to occur in Huntington's disease (HD), a hereditary neurodegenerative disorder. Less is known about the occurrence and cohesion of whole brain grey matter changes in HD. Objectives: We aimed to detect
Emma M. Coppen, Jeroen van der Grond, Anne Hafkemeijer, Serge A.R.B. Rombouts, Raymund A.C Roos   +4 more
doaj   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

The thalamic covariance network is associated with cognitive deficits in patients with cerebral small vascular disease

Annals of Clinical and Translational Neurology
Objective Abnormalities in the gray matter structure of cerebral small vessel disease (CSVD) have been observed throughout the brain. However, whether cortico‐cortical connections exist between regions of gray matter atrophy in patients with CSVD has not
Wei Yan, Siwei Tang, Li Chen, Ting Lei, Haiqing Li, Yuxing Jiang, Miao He, Lijing Zhou, Yajun Li, Chen Zeng, Hongjian Li   +10 more
doaj   +1 more source

Laminar thickness covariance in association to structural covariance.

, 2023
(a) The structural covariance matrix based on cortical thickness (left) in association with the laminar thickness covariance (LTC; center left). Main axes of structural covariance (center right) and LTC were correlated (right).
Amin Saberi (17364814), Casey Paquola (6714824), Meike D. Hettwer (17364817), Simon B. Eickhoff (8355852), Konrad Wagstyl (6714830), Sofie L. Valk (11304534), Boris C. Bernhardt (3318705)   +6 more
core   +1 more source

Coexisting Volatile and Nonvolatile Switching in 3D ALD‐IGZO Vertical RRAM for Fully Hardware‐Based Wide Reservoir Computing

Advanced Science, EarlyView.
A conformal ALD‐IGZO vertical RRAM integrates volatile and nonvolatile switching within a compact 2F architecture. Before forming, tunable volatile dynamics provide fading‐memory reservoir states, while after forming, stable multilevel conductance modulation enables hardware readout.
Seeun Lee, Jaewon Park, Nawoon Kim, Seohyeon Ju, Seong‐Cheol Jang, Hyun‐Suk Kim, Sungjun Kim   +6 more
wiley   +1 more source

Connectivity analysis with structural equation modelling: an example of the effects of voxel selection [PDF]

, 2003
Structural equation modelling (SEM) of neuroimaging data is commonly applied to a network of distributed brain regions. We applied SEM to an fMRI dataset to identify condition-specific effects in a simple experiment composed of visual stimulation and ...
Hall, Deborah A.; id_orcid, Gonçalves, MS, Hall, DA, Gonçalves, Miguel S.   +3 more
core   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Gray matter volume and structural covariance alterations in young males with childhood-onset growth hormone deficiency

BMC Medical Imaging
Purpose This study investigated the differences in gray matter volume (GMV), structural covariance, and structural covariance networks between adults with childhood-onset growth hormone deficiency (GHD) and healthy controls (HCs). Materials and methods A
Shengyu Wang, Wenting Su, Xiao Liu, Yue Zhao, Ming Zhang, Lunbo Lu, Suzhen Zhang, Dongmei Wang, Wenjie Yang, Yuwen Zhang, Xinping Kuai   +10 more
doaj   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source