Results 31 to 40 of about 4,915,641 (298)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Tenascin-C fragments are endogenous inducers of cartilage matrix degradation [PDF]

, 2011
Cartilage destruction is a hallmark of osteoarthritis (OA) and is characterized by increased protease activity resulting in the degradation of critical extracellular matrix (ECM) proteins essential for maintaining cartilage integrity.
Hermansson, M, Saralili Dipa Robertson, Wait, R, Robertson, SD, Wait, Robin, Monika Hermansson, Jonathan Jones, Philip Mitchell, Mitchell, P, Sofat, N, Nidhi Sofat, Jones, J, Robin Wait   +12 more
core   +1 more source

Degradation and Sustainability: Analysis of Structural Issues in the Eduardo Caldeira Bridge, Machico

Infrastructures
This paper presents a detailed analysis of the severe structural anomalies that led to the urgent rehabilitation of the Eduardo Caldeira Bridge in Machico, Madeira.
Raul Alves, Sérgio Lousada, José Manuel Naranjo Gómez, José Cabezas   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Accurate prediction of structural degradation in diesel engine cylinder blocks based on component scaling methods

Frontiers in Aerospace Engineering
This paper proposes a method that significantly improves the prediction accuracy of structural degradation in the main bearing wall of diesel engine cylinders.
Weiqing Huang, Cheng Xu, Min Liu, Yixuan Fu   +3 more
doaj   +1 more source

Correlation between System Entropy and Structural Changes in Lubricating Grease

Lubricants, 2015
Lubricating greases are colloid disperse systems consisting of a base oil and a thickener (additional additives). The lubricant is modeled as a tribological system, and the reaction of a fluid friction stress is investigated.
Erik Kuhn
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The structural reliability of bridges subject to time-dependent deterioration [PDF]

, 2007
Paper presented at the 11th International Conference on Civil, Structural and Environmental Engineering Computing, Malta, 18-21 September 2007The reliability of the structural performance of any given structure is affected by both in-service loading and ...
Bordallo-Ruiz, A., E.J. OBrien, O'Brien, Eugene J., C.C. Caprani, O\u27Brien, E. J., McNally, C., C. McNally, McNally, Ciaran, Bordallo-Ruiz, Alberto, Caprani, Colin C., A. Bordallo-Ruiz   +10 more
core   +1 more source

A Data-Driven Strategy for the Structural Health Monitoring of the Machico Cable-Stayed Bridge: A Case Study

Buildings
The management of aging infrastructure requires a paradigm shift from routine, time-based inspections to data-driven, condition-based assessment. This paper presents a novel and practical framework for this transition through an in-depth case study of ...
Raul Alves, Sérgio Lousada, Dainora Jankauskienė, Vivita Pukite   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source