Results 41 to 50 of about 4,915,641 (298)

Identification, isolation, and structural characterization of novel forced degradation products of Ertugliflozin using advanced analytical techniques

Scientific Reports, 2023
The research elucidates the stress degradation behavior of Ertugliflozin, which is used for the treatment of type-2 diabetics. The degradation was conducted as per ICH guidelines and Ertugliflozin is relatively stable in thermal, photolytic, neutral, and
Suresh Salakolusu, Naresh Kumar Katari, Ganapavarapu Veera Raghava Sharma, Muralidharan Kaliyaperumal, Umamaheshwar Puppala, Mahesh Ranga, Sreekantha Babu Jonnalagadda   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

STRUCTURAL ASPECTS OF CYCLICAL STRENGTH OF A SUPERHEATER WELDMENT

Известия Томского политехнического университета: Инжиниринг георесурсов, 2019
The relevance of researching power generator weldments is associated with the necessity of increasing the operational reliability of the heat-power equipment frequently damaged and most critical units. One of the working efficiency increasing factors is
doaj   +1 more source

Structural Degradation of O3-NaMnO₂ Positive Electrodes in Sodium-Ion Batteries

Crystals, 2022
In this manuscript, we report an extensive study of the physico-chemical properties of different samples of O3-NaMnO2, synthesized by sol–gel and solid state methods. In order to successfully synthesize the materials by sol–gel methods a rigorous control
Matteo Palluzzi, Laura Silvestri, Arcangelo Celeste, Mariarosaria Tuccillo, Alessandro Latini, Sergio Brutti   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Advances in Modelling and Analysis of Strength of Corroded Ship Structures

Journal of Marine Science and Engineering, 2022
The present study reviews the recent advances in modelling and analyses the strength of corroded ship structures. Firstly, the time-variant methodologies that consider only the mean structural element thickness loss due to corrosion degradation are ...
Krzysztof Woloszyk, Yordan Garbatov
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Structural optimisation of diffusion driven degradation processes [Elektronisk resurs]

, 2021
In this article, we propose an optimisation framework that can contribute to the prevention of premature failure or damage to building structures and can thereby strengthen their longevity.
Lund University., Waschinsky, Navina,, Barthold, Franz Joseph,, Menzel, Andreas,   +3 more
core   +1 more source