Results 61 to 70 of about 4,915,641 (298)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Design and structural characterisation of olfactomedin-1 variants as tools for functional studies [PDF]

, 2019
Background Olfactomedin-1 (Olfm1; also known as Noelin or Pancortin) is a highly-expressed secreted brain and retina protein and its four isoforms have different roles in nervous system development and function.
Sub Crystal and Structural Chemistry, Van den Hoek, H., Crystal and Structural Chemistry, Janssen, Bert J. C., Pronker, M., Van Den Hoek, Hugo, Janssen, B., Pronker, Matti F.   +7 more
core   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Development of a Large Database of Italian Bridge Bearings: Preliminary Analysis of Collected Data and Typical Defects

Infrastructures
This paper presents the development and analysis of a bridge bearing database consistent with the 2020 Italian Guidelines (LG2020), currently enforced by the Italian law for risk classification and management of existing bridges.
Angelo Masi, Giuseppe Santarsiero, Marco Savoia, Enrico Cardillo, Beatrice Belletti, Ruggero Macaluso, Maurizio Orlando, Giovanni Menichini, Giacomo Morano, Giuseppe Carlo Marano, Fabrizio Palmisano, Anna Saetta, Luisa Berto, Maria Rosaria Pecce, Antonio Bilotta, Pier Paolo Rossi, Andrea Floridia, Mauro Sassu, Marco Zucca, Eugenio Chioccarelli, Alberto Meda, Daniele Losanno, Marco Di Prisco, Giorgio Serino, Paolo Riva, Nicola Nisticò, Sergio Lagomarsino, Stefania Degli Abbati, Giuseppe Maddaloni, Gennaro Magliulo, Mattia Calò, Fabio Biondini, Francesca da Porto, Daniele Zonta, Maria Pina Limongelli   +34 more
doaj   +1 more source

Degradation in Seawater of Structural Adhesives for Hybrid Fibre-Metal Laminated Materials

Advances in Materials Science and Engineering, 2013
The adhesives used for applications in marine environments are subject to particular chemical conditions, which are mainly characterised by an elevated chlorine ion content and intermittent wetting/drying cycles, among others.
Cristina Alia, María V. Biezma, Paz Pinilla, José M. Arenas, Juan C. Suárez   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Sorting out Sortilins: structural studies on the VPS10 family [PDF]

, 2017
The topic of this dissertation is the structural characterization of the VPS10 receptors Sortilin and SorCS2, as well as their interactions with proneurotrophins.
Sub Crystal and Structural Chemistry, Crystal and Structural Chemistry, Leloup, N.O.L.   +2 more
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source