Results 81 to 90 of about 4,915,641 (298)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Degradation of BTEX by anaerobic bacteria: physiology and application [PDF]

, 2010
Pollution of the environment with aromatic hydrocarbons, such as benzene, toluene, ethylbenzene and xylene (so-called BTEX) is often observed. The cleanup of these toxic compounds has gained much attention in the last decades.
Weelink, S.A.B., Stams, A.J.M., Eekert, M.H.A., van   +2 more
core   +1 more source

The Arg/N-degron pathway mediates the secretion of apoptotic exosomes under oxidative stress in cancer cell

iScience
Summary: Exosomes from cancer cells are versatile mediators of cell-to-cell communication, whose cargoes are dynamically loaded in response to various stress conditions.
Su Bin Kim, Ji Su Lee, Chan Hoon Jung, Eun Hye Cho, Ho Seok Seo, Gee Eun Lee, Hye Yeon Kim, Su Jin Lee, Min Ju Lee, Hans Jin-young Oh, Ah Jung Heo, Do Hyun Han, Yong Tae Kwon, Chang Hoon Ji   +13 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Structural and functional studies on Nod Like Receptors: insights into NAIP/NLRC4 inflammasome formation [PDF]

, 2013
Our immune system is under constant attack of invading pathogens. The initiation of an appropriate immune response that leads to clearance of these microorganisms and infected cells is dependent on the ability of the immune system to discern between ...
Sub Crystal and Structural Chemistry, Crystal and Structural Chemistry, Halff, E.F.   +2 more
core  

Degradation

, 2018
.csv file with data for analysis of telomere degradation over time (ie., number of years sample was stored)
Timothy Greives (3240711), Carolyn Bauer (5012888), Ellen Ketterson (451058), Jessica Graham (4342558), Britt Heidinger (4446874)   +4 more
core   +1 more source

Bayesian Optimization-Based Parameter Identification for Discrete Element Method Simulation of Consolidation and Its Application to Powder Spreading Analysis

Journal of Manufacturing and Materials Processing
This study develops a Bayesian optimization framework to calibrate two discrete element method (DEM) parameters—the cohesion-related surface energy coefficient (k) and the rolling resistance coefficient (μr)—based on experimental void ratio data obtained
Jun Katagiri, Masahiro Kusano, Makoto Watanabe   +2 more
doaj   +1 more source

Determining Lignin Degradation in White-Rot Fungi-Treated Sacrau Poplar: Lignin Structural Changes and Degradation Compound Analysis

BioResources, 2016
Determining the structural changes of lignin during bio-treatment will facilitate the understanding of biomass recalcitrance during the sustainable production of chemicals and fuels.
Liming Zhang, Tingting You, Tian Zhou, Lu Zhang, Feng Xu   +4 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Structural and mechanistic insights into Dis3L2–mediated degradation of structured RNA

RNA
Abstract The RNase II/RNB family of exoribonucleases is present in all domains of life and includes three main eukaryotic members, the Dis3-like proteins (Dis3, Dis3L1, Dis3L2). At the cellular level, Dis3L2 is distinguished by the unique preference for uridylated RNA substrates and the highest efficiency in degrading
Rute G. Matos, Ankur Garg, Susana M. Costa, Patrícia Pereira, Cecília M. Arraiano, Leemor Joshua-Tor, Sandra C. Viegas   +6 more
openaire   +2 more sources