Results 91 to 100 of about 4,915,641 (298)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
The IPBES assessment report on land degradation and restoration
, 2019 The Assessment Report on Land Degradation and Restoration by the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) provides a critical analysis of the state of knowledge regarding the importance, drivers, status,
IPBES Land degradation assessment collaboration
core +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Pharmaceuticals, 2010 In the attempt to discover a new polymorph of rofecoxib (Vioxx®), an unexpected product resulted. The product was characterised by chemical composition, thermal behaviour and structure and found to be 6-methylsulphonylphenanthro-[9,10-C] furan-1(3H)-one,
Pamela M. Dean
doaj +1 more source
Degradation of structural ceramics by erosion [PDF]
Journal of Nondestructive Evaluation, 1996 Materials wastage by solid-particle erosion can be severe and limit lifetimes. This paper will review the theoretical description of solid-particle erosion in brittle materials, which is well-developed for monolithic ceramics. The models can usually account for effects from the principal projectile properties: size, impact velocity, and impact angle ...
openaire +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
The effect of degradation on the structural response of a reinforced concrete arch bridge [PDF]
In recent years, several bridge collapses have occurred worldwide, resulting in human life and economic direct and non-direct losses. Such events are likely related to the age of bridges, which is approaching their lifespan in most of the cases ...
Francesco Micelli +4 more
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
In Vivo Degradation Behavior of the Magnesium Alloy LANd442 in Rabbit Tibiae [PDF]
, 2011 In former studies the magnesium alloy LAE442 showed promising in vivo degradation behavior and biocompatibility. However, reproducibility might be enhanced by replacement of the rare earth composition metal "E" by only a single rare earth element ...
Reifenrath, Janin +11 more
core +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source