Structural insights into the Clp protein degradation machinery
mBioThe Clp protease system is important for maintaining proteostasis in bacteria. It consists of ClpP serine proteases and an AAA+ Clp-ATPase such as ClpC1.
Xiaolong Xu +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Structural insight into molecular mechanism of poly(ethylene terephthalate) degradation
Nature Communications, 2018 Poly(ethylene terephthalate) (PET) is a widely used plastic and its accumulation in the environment has become global problem. Here the authors report the crystal structure of a Ideonella sakaiensis PET-degrading enzyme and propose a molecular mechanism ...
Seongjoon Joo +8 more
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Structural studies of human cell surface receptors: On low-density lipoprotein receptor-related protein 1 and epidermal growth factor receptors 2 and 3 [PDF]
, 2017 The elucidation of proteins’ structure and function is of great importance for the understanding of disease triggering mechanisms and for the development of new drugs. In this thesis, different biophysical and biochemical techniques were employed to gain
Sub Crystal and Structural Chemistry +2 more
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PROTAC-induced protein structural dynamics in targeted protein degradation
eLifePROteolysis TArgeting Chimeras (PROTACs) are small molecules that induce target protein degradation via the ubiquitin-proteasome system. PROTACs recruit the target protein and E3 ligase; a critical first step is forming a ternary complex.
Kingsley Y Wu +2 more
doaj +1 more source
The contribution of soil structural degradation to catchment flooding: a preliminary investigation of the 2000 floods in England and Wales [PDF]
Hydrology and Earth System Sciences, 2003 During the autumn of 2000, England and Wales experienced the wettest conditions for over 270 years, causing significant flooding. The exceptional combination of a wet spring and autumn provided the potential for soil structural degradation.
I. P. Holman +4 more
doaj
Structural Degradation in Midcingulate Cortex Is Associated with Pathological Aggression in Mice. [PDF]
Brain Sci, 2021 Heukelum SV +9 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Understanding the first steps of the complement classical pathway: Structural studies on C1-antibody complexes [PDF]
, 2018 The complement system is a complex network of plasma and membrane-associated proteins, which can produce effective immune responses to infectious micro-organisms. Deficiencies of complement proteins cause diseases like systemic lupus erythematosus (SLE),
Sub Crystal and Structural Chemistry +2 more
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