Results 141 to 150 of about 6,591,436 (258)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Some Structural Elements of Bacterial Protein MF3 That Influence Its Ability to Induce Plant Resistance to Fungi, Viruses, and Other Plant Pathogens. [PDF]

Int J Mol Sci, 2023
Erokhin D, Popletaeva S, Sinelnikov I, Rozhkova A, Shcherbakova L, Dzhavakhiya V.   +5 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Enhancing the fatigue life approach by the usage of Representative Structural Elements

151160Additively manufactured metallic structures offer enormous lightweight potential, which must be exploited for components subjected to cyclic loads.
Kiel, Marvin, Wagener, Rainer
core   +1 more source

CAR-T cell potency: from structural elements to vector backbone components. [PDF]

Biomark Res, 2022
Mazinani M, Rahbarizadeh F.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Structural failures in buildings

, 1984
12.00; first published 1981Available from British Library Document Supply Centre- DSC:86/16582(Structural) / BLDSC - British Library Document Supply CentreSIGLEGBUnited ...
Institution of Structural Engineers (ISE), London (United Kingdom)
core  

THE REVISED CRITERION OF PISARENKO-LEBEDEV TO EVALUATE THE STRESS STATE OF STRUCTURAL ELEMENTS OF BUILDINGS AND STRUCTURES

Nauka ta progres transportu, 2007
The improved variant of Pisarenko-Lebedev criterion for estimation of a stress limit state for materials of building structures is presented. It has been obtained with taking into account the maximal residual tensile stresses acting in a localized zone.
V. S. Shokaev
doaj  

Determination of oligosaccharide product distributions of PL7 alginate lyases by their structural elements. [PDF]

Commun Biol, 2022
Zhang K, Li Z, Zhu Q, Cao H, He X, Zhang XH, Liu W, Lyu Q.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source