Results 151 to 160 of about 6,591,436 (258)

Quelques elements structurels et economiques de l'agriculture belge.

Quelques elements structurels et economiques de l'agriculture ...
Elements
core  

Structural elements that enable specificity for mutant EGFR kinase domains with next-generation small-molecule inhibitors. [PDF]

Methods Enzymol, 2023
Damghani T, Wittlinger F, Beyett TS, Eck MJ, Laufer SA, Heppner DE.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Spatial-structural interaction and strain energy structural optimisation

, 2012
A research engine iteratively transforms spatial designs into structural designs and vice versa. Furthermore, spatial and structural designs are optimised.
Wilde, de, P., Davila Delgado, J.M., Hofmeyer, H., Borrmann, A., Rafiq, Y., Geyer, P.   +5 more
core  

Structural Characteristics and Properties of Zinc Coatings on Steel Structural Elements. [PDF]

Materials (Basel)
Witkowska M, Kowalski M, Kowalska J, Chronowska-Przywara K.   +3 more
europepmc   +1 more source

Theoretical and Experimental Studies of the Impact of High-Speed Raindrops on the Structural Elements of Modern Technology. [PDF]

Materials (Basel), 2022
Sun Y, Pronina PF, Rabinskiy LN, Tushavina OV.   +3 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Weld acoustic emission inspection of structural elements embedded in concrete. [PDF]

Sci Prog, 2022
Carrion-Viramontes FJ, Hernandez-Figueroa JA, Machorro-Lopez JM, Quintana-Rodriguez JA, Crespo-Sanchez SE, Martinez-Trujano LA, Gasca-Zamora HM.   +6 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Characterization and Computational Engineering of Structural Elements Controlling Gas Permeability in PIP2;1 Aquaporins. [PDF]

J Comput Chem
Najafi AR, Mahinthichaichan P, Moss FJ, Vahedi-Faridi A, Boron WF, Tajkhorshid E.   +5 more
europepmc   +1 more source