Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Photocatalytic CO<sub>2</sub> Reduction over Cotton-like Blue C/TiO<sub>2</sub> Nanotubes: Enhanced Performance via Structural Engineering. [PDF]
Wu W, Yang Z, Zhang M, Guan Z, Yang J.
europepmc +1 more source
Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens. [PDF]
Hwang MS +21 more
europepmc +1 more source
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
Structural engineering of BiOBr nanosheets for boosted photodegradation performance toward rhodamine B. [PDF]
Qi Y, Zhao J, Wang H, Yan M, Guo T.
europepmc +1 more source
Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon +12 more
wiley +1 more source
Ultrastrong eutectogels engineered via integrated mechanical training in molecular and structural engineering. [PDF]
Xu C +6 more
europepmc +1 more source
Structural Engineering of Fluorescent Self-Threaded Peptide Probes for Targeted Cell Imaging. [PDF]
Schreiber CL, Zhai C, Smith BD.
europepmc +1 more source
Structural Engineering of pMHC Reagents for T Cell Vaccines and Diagnostics
Vesselin Mitaksov +5 more
openalex +2 more sources

