Results 31 to 40 of about 671,923 (262)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Materials and Structures Used in Aeronautics: Present and Future Perspectives [PDF]

INCAS Bulletin
In recent years, significant advancements have been made in the development of novel materials for aeronautic applications. This effort aims to reduce costs by extending the operational life of structural and engine components, improving fuel economy ...
Mihai FLOREA, Vlad-Stefan CONSTANTIN, Andrei-Christian BUCUR, Raluca FAUR, Denis PREDU, Alexandru CAZACU   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Contribution to probabilistic modeling of soil geo-mechanical properties for structural reliability analysis of buried pipes and foundations

Journal of Materials and Engineering Structures, 2019
This present study synthesizes a numerical approach to optimize foundation systems design and underground pipes based on the combination of elastoplastic soil behavior and probabilistic modeling of its geo-mechanical characteristics.
Nabil KAZI TANI, Djamel NEDJAR, Tawfik TAMINE, Mabrouk HAMANE   +3 more
doaj  

Artificial Intelligence-Based Design and Analysis of Passive Control Structures: An Overview [PDF]

Journal of Soft Computing in Civil Engineering
Recently, artificial intelligence (AI) has been widely adopted in the design and analysis of passively controlled structures. This study provides a comprehensive overview of AI-based methodologies aimed at enhancing the resilience and efficiency of ...
Ausamah AL Houri, Ahed Habib, Zaid A. Al-Sadoon   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structure-guided engineering and molecular simulations to design a potent monoclonal antibody to target aP2 antigen for adaptive immune response instigation against type 2 diabetes

Frontiers in Immunology
IntroductionDiabetes mellitus (DM) is recognized as one of the oldest chronic diseases and has become a significant public health issue, necessitating innovative therapeutic strategies to enhance patient outcomes.
Abbas Khan, Muhammad Ammar Zahid, Anwar Mohammad, Abdelali Agouni   +3 more
doaj   +1 more source

Discrete Sizing Optimization of Steel Structures Using Modified Fireworks Algorithm [PDF]

Journal of Soft Computing in Civil Engineering
Fireworks algorithm (FWA) is an artificial intelligence algorithm developed by emulating the burst process of fireworks. This paper applies a modified version of fireworks algorithm called MoFWA to design disparate steel trusses and planar frames.
Navid Seraji, Mehdi Babaei
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source