Results 41 to 50 of about 855,547 (311)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Journal of Materials and Engineering Structures, 2019 This present study synthesizes a numerical approach to optimize foundation systems design and underground pipes based on the combination of elastoplastic soil behavior and probabilistic modeling of its geo-mechanical characteristics.
Nabil KAZI TANI +3 more
doaj
DUCTILITY AND STRENGTH OF REINFORCED CONCRETE BEAMS INTRINSICALLY REINFORCED WITH POLYPROPYLENE FIBRES [PDF]
, 2013 The Thirteenth East Asia-Pacific Conference on Structural Engineering and Construction (EASEC-13), September 11-13, 2013, Sapporo ...
GHOSNI, N. +8 more
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Structures and functions of the inflammasome engine
Journal of Allergy and Clinical Immunology, 2021 Inflammasomes are molecular machines that carry out inflammatory responses on challenges by pathogens and endogenous dangers. Dysregulation of inflammasome assembly and regulation is associated with numerous human diseases from autoimmunity to cancer.
Longfei Wang +4 more
openaire +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Influence of coherent structure on turbulence characteristics of 0814 strong typhoon Hagupit
Shenzhen Daxue xuebao. Ligong ban, 2022 In order to explore the formation mechanism of the nonstationary wind speed in the eye wall regions and eye region of a typhoon, taking the measured data of No.0814 strong typhoon Hagupit as the research object, we identify and extract the coherent ...
LI Lixiao +5 more
doaj +1 more source
PERFORMANCE OF POLYMER-CONCRETE COMPOSITES EXPOSED TO SEVERE ENVIRONMENT [PDF]
, 2013 The Thirteenth East Asia-Pacific Conference on Structural Engineering and Construction (EASEC-13), September 11-13, 2013, Sapporo ...
Nejadi, S +8 more
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