Results 61 to 70 of about 855,547 (311)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Seismic vulnerability of existing buildings: non-invasive approach for dynamic behaviour assessment

open access: yesGEOmedia, 2018
This paper presents a brief overview of the concept of seismic risk, with particular regard to existing civil buildings. Given that the seismic risk can be expressed as a combination involving seismic hazard and seismic vulnerability, these aspects are ...
Gianluca Acunzo   +2 more
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

9th Structural Engineering Convention 2014

open access: yes, 2015
The book presents research papers presented by academicians, researchers, and practicing structural engineers from India and abroad in the recently held Structural Engineering Convention (SEC) 2014 at Indian Institute of Technology Delhi during 22 – 24 ...
Matsagar, Vasant
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

A Neuro-Symbolic Framework for Ensuring Deterministic Reliability in AI-Assisted Structural Engineering: The SYNAPSE Architecture

open access: yesBuildings
This paper addresses the opportunities and risks of integrating Large Language Models (LLMs) into structural engineering. Exclusive reliance on LLMs is inadequate in this field, because their probabilistic nature can lead to hallucinations and ...
Adriano Castagnone, Giuseppe Nitti
doaj   +1 more source

INVESTIGATION OF MECHANICAL PROPERTIES OF A NEW TYPE OF ACID RESISTANT CONCRETE [PDF]

open access: yes, 2013
The Thirteenth East Asia-Pacific Conference on Structural Engineering and Construction (EASEC-13), September 11-13, 2013, Sapporo ...
Adam, Georgius A. (R18230)   +5 more
core  

Advances in Frontier Research on Engineering Structures

open access: yes, 2023
This is an open access book. This book focuses on the research of advanced structures and anti-seismic in civil engineering. It features the most cutting-edge research directions and achievements related to civil and structural engineering.

core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

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