Results 51 to 60 of about 26,686 (263)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Numerical Methods for Topological Optimization of Wooden Structural Elements

Buildings
Timber represents a building material that aligns with the environmental demands on the impact of the construction sector on climate change. The most common engineering solution for modern timber buildings with large spans is glued laminate timber ...
Daniela Țăpuși, Andrei-Dan Sabău, Adrian-Alexandru Savu, Ruxandra-Irina Erbașu, Ioana Teodorescu   +4 more
doaj   +1 more source

Structural Stability Evaluation of Existing Buildings by Reverse Engineering with 3D Laser Scanner

Remote Sensing, 2022
In the Fourth Industrial Revolution, research and development of application technologies that combine high-tech technologies have been actively conducted.
Arum Jang, Young K. Ju, Min Jae Park
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Monitoring and Control of Structural Vibrations

Applied Sciences
Monitoring and control of structural vibrations are crucial to ensure structural safety and vibration comfort of civil engineering structures, such as buildings, bridges, tunnels, antennas, stadia etc [...]
Felix Weber
doaj   +1 more source

The Diagnostics of the Condition and Management of Large-Panel Buildings Using Point Clouds and Building Information Modelling (BIM)

Buildings, 2023
Technological developments involving the implementation of modern measuring equipment and the digitalisation of civil engineering can contribute to extending the service life of buildings. Large-panel buildings constitute a large housing stock throughout
Maciej Wardach, Joanna Agnieszka Pawłowicz, Marta Kosior-Kazberuk, Janusz Ryszard Krentowski   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An mass ratio of permanent loads to variable loads of reinforced concrete buildings

Journal of Asian Architecture and Building Engineering
Environmental and resource crises necessitate sustainable development, yet construction lags in material conservation and carbon mitigation. Extensive use of reinforced concrete results in excessive permanent loads and larger building self-weight ...
Wanghu Sun, Yuning Sun, Chen Liu
doaj   +1 more source

Seismic Evaluation and Methods of Rehabilitation of Old Masonry Buildings in the Bay of Kotor (Montenegro)

Applied Sciences, 2021
Old load-bearing masonry buildings exist all around the world. The cultural and architectural heritage value of these buildings and the consciousness of public opinion have led to a need for safeguarding and preservation policies for these ...
Dušan Tomanović, Ljubo Marković, Nebojša Gadžić, Irena Rajković, Julija Aleksić, Tijana Tomanović   +5 more
doaj   +1 more source