Results 41 to 50 of about 1,005,503 (330)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Structural equation modeling approach between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia: an ICA resting-state fMRI study

Neuropsychiatric Disease and Treatment, 2018
Masashi Ohta,1 Masahito Nakataki,1 Tomoya Takeda,1 Shusuke Numata,1 Takeo Tominaga,1 Naomi Kameoka,2 Hiroko Kubo,1 Makoto Kinoshita,1 Kanae Matsuura,2 Maki Otomo,3 Naoya Takeichi,4 Masafumi Harada,3 Tetsuro Ohmori1 1Department of Psychiatry, Graduate ...
Ohta M, Nakataki M, Takeda T, Numata S, Tominaga T, Kameoka N, Kubo H, Kinoshita M, Matsuura K, Otomo M, Takeichi N, Harada M, Ohmori T   +12 more
doaj  

Exploring the Students’ Perceived Effectiveness of Online Education during the COVID-19 Pandemic: Empirical Analysis Using Structural Equation Modeling (SEM) [PDF]

, 2023
Qamar Ali, Azhar Abbas, Ali Raza, Muhammad Tariq Iqbal Khan, Hasan Zulfiqar, Muhammad Amjed Iqbal, Roshan Nayak, Bader Alhafi Alotaibi   +7 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Structural equation modeling analysis of social support, coping strategies, depression and suicidal ideation among people living with HIV/AIDS in Changsha, China

Neuropsychiatric Disease and Treatment, 2018
Xun Tang,1 Hui-Ying Wang,1 Min Wang,2 Xiao-Hua Ren,3 Fu-Rong Jiang,1 Jian-Ling Li1,3 1Clinical Psychology Department of Xiangya Hospital, Xiangya Medical School, Central South University, Changsha, China; 2Department of HIV, The First Hospital of ...
Tang X, Wang HY, Wang M, Ren XH, Jiang FR, Li JL   +5 more
doaj  

PREDICTING CONTINUANCE INTENTION AND USE OF MOBILE SHOPPING APPS WITH PLS-SEM AND NECESSARY CONDITION ANALYSIS IN TANDEM [PDF]

Journal of Applied Structural Equation Modeling
The adoption of multi-channel strategies by retailers, encompassing both online and offline modalities, has fundamentally transformed consumer shopping behaviors, resulting in a significant increase in mobile shopping.
Kin Leong Tang, Pei Meng Tan, Rae Hooi, Mei Peng Low, Kok Eng Tan, Kai Ching Yeo   +5 more
doaj   +1 more source

Exploring the complex relationships between coping strategies, locus of control and self-esteem with psychopathology: structural equation modeling with a special focus on clinical high-risk of psychosis [PDF]

, 2023
Giulia Rinaldi, Naweed Osman, Michael Kaess, Benno G. Schimmelmann, Jochen Kindler, Frauke Schultze‐Lutter, Chantal Michel   +6 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

THE MEDIATING ROLE OF GREEN IMAGE BETWEEN SOCIAL MEDIA ATTRIBUTES AND THE INTENTION TO REVISIT GREEN RESORTS [PDF]

Journal of Applied Structural Equation Modeling
This study aims to investigate social media attributes—including sharing of content, accessibility, and credibility—that can impact a tourist's intention to revisit green resorts.
Tak Jie Chan, Aminath Raushan Imad
doaj   +1 more source

Parent-child communication about internet use and acceptance of parental authority

, 2020
Structural equation modeling is applied to investigate how parents' communication with their child about his or her Internet use is linked to the child's acceptance of parental authority in the context of Internet use, and how this in turn is linked to ...
Ponnet, Koen, Symons, Katrien, Van Ouytsel, Joris, Vanwesenbeeck, Ini, Walrave, Michel   +4 more
core   +1 more source