FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability. [PDF]
Sci Rep, 2023 Takechi-Haraya Y +12 more
europepmc +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide. [PDF]
Nucleic Acids Res, 2023 Troisi R +8 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source
The Structural Flexibility of PR-10 Food Allergens. [PDF]
Int J Mol Sci, 2022 Führer S +6 more
europepmc +1 more source
Advancing Stroke Clinical Trials Using Community Engagement and Implementation Science Approaches
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Stroke clinical trials are essential for advancing stroke care but can face challenges with recruitment, retention, clinical relevance, and translation into real‐world practice. We propose that integrating community engagement and implementation science approaches into stroke trials can help address these needs.
Lesli E. Skolarus +2 more
wiley +1 more source
The Manufacturing Flexibility to Switch Products: Valuation and Optimal Strategy [PDF]
This paper applies a dynamic programming methodology to the valuation problem for the flexibility to switch. In our model, flexibility provides an investor with the right, or option, to perform a switch between a less profitable and a more profitable ...
Sorin Tuluca, Piotr Stalinski
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On the complexity of IgE: The role of structural flexibility and glycosylation for binding its receptors. [PDF]
Front Allergy, 2023 Plattner K, Bachmann MF, Vogel M.
europepmc +1 more source
Mixed-linker strategy for suppressing structural flexibility of metal-organic framework membranes for gas separation. [PDF]
Commun Chem, 2023 Chang CK +8 more
europepmc +1 more source