BiologyThe enzyme acetylcholinesterase (AChE) plays a crucial role in the termination of nerve impulses by hydrolyzing the neurotransmitter acetylcholine (ACh).
Ysaías J. Alvarado +11 more
doaj +1 more source
Nickel and GTP Modulate Helicobacter pylori UreG Structural Flexibility
Biomolecules, 2020 UreG is a P-loop GTP hydrolase involved in the maturation of nickel-containing urease, an essential enzyme found in plants, fungi, bacteria, and archaea.
Annalisa Pierro +7 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Adaptive control of robotic manipulators with structural flexibility.
, 1991 Adaptive control of robotic manipulators with structural ...
Sijun. Wu (7976018)
core +3 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Effect of sedentary lifestyle, nutritional status and sex on the flexibility of students [PDF]
, 2014 INTRODUCTION: assart-day life habits have led to a more sedentary lifestyle, contributing to increased obesity. In view of these changes, it is necessary to understand whether the flexibility of the individual has also been influenced.
Martinello, Micheli +5 more
core +1 more source
Succession Planning, Strategic Flexibility as Predictors of Business Sustainability in FamilyOwned SMEs: Moderating Role of Organization Improvisation [PDF]
Pakistan Journal of Commerce and Social Sciences, 2020 The objective of the current study is to test the impact of succession planning (cognitive, structural, and relational ties), strategic flexibility, and organizational improvisation towards the business sustainability considering the triple bottom line
Ijaz Hussain Bokhari +2 more
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Exploring the potential of a structural alphabet-based tool for mining multiple target conformations and target flexibility insight. [PDF]
PLoS ONE, 2017 Protein flexibility is often implied in binding with different partners and is essential for protein function. The growing number of macromolecular structures in the Protein Data Bank entries and their redundancy has become a major source of structural ...
Leslie Regad +5 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source