Results 41 to 50 of about 4,240,825 (290)

Flexible Structure Learning Under Uncertainty

SSRN Electronic Journal, 2022
Experience is known to facilitate our ability to interpret sequences of events and make predictions about the future by extracting temporal regularities in our environments. Here, we ask whether uncertainty in dynamic environments affects our ability to learn predictive structures.
Rui Wang, Rui Wang, Vael Gates, Yuan Shen, Peter Tino, Zoe Kourtzi   +5 more
openaire   +4 more sources

Protein flexibility in the light of structural alphabets

Frontiers in Molecular Biosciences, 2015
Protein structures are valuable tools to understand protein function. Nonetheless, proteins are often considered as rigid macromolecules while their structures exhibit specific flexibility, which is essential to complete their functions.
Pierrick eCraveur, Pierrick eCraveur, Pierrick eCraveur, Pierrick eCraveur, Agnel Praveen eJoseph, Jeremy eEsque, Tarun JaiRaj eNarwani, Tarun JaiRaj eNarwani, Tarun JaiRaj eNarwani, Tarun JaiRaj eNarwani, Floriane eNoel, Floriane eNoel, Floriane eNoel, Floriane eNoel, Nicolas eShinada, Nicolas eShinada, Nicolas eShinada, Nicolas eShinada, Matthieu eGoguet, Matthieu eGoguet, Matthieu eGoguet, Matthieu eGoguet, Léonard eSylvain, Léonard eSylvain, Léonard eSylvain, Léonard eSylvain, Pierre ePoulain, Pierre ePoulain, Pierre ePoulain, Pierre ePoulain, Pierre ePoulain, Olivier eBertrand, Olivier eBertrand, Olivier eBertrand, Olivier eBertrand, Guilhem eFaure, Joseph eRebehmed, Amine eGhozlane, Lakshmipuram S Swapna, Lakshmipuram S Swapna, Ramachandra M Bhaskara, Ramachandra M Bhaskara, Jonathan eBarnoud, Jonathan eBarnoud, Jonathan eBarnoud, Jonathan eBarnoud, Jonathan eBarnoud, Stéphane eTéletchéa, Stéphane eTéletchéa, Stéphane eTéletchéa, Stéphane eTéletchéa, Stéphane eTéletchéa, Vincent eJallu, Jiri eCerny, Bohdan eSchneider, Catherine eEtchebest, Catherine eEtchebest, Catherine eEtchebest, Catherine eEtchebest, Narayanaswamy eSrinivasan, Jean-Christophe eGelly, Jean-Christophe eGelly, Jean-Christophe eGelly, Jean-Christophe eGelly, Alexandre G. de Brevern, Alexandre G. de Brevern, Alexandre G. de Brevern, Alexandre G. de Brevern   +67 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Structural Changes of Yellow Cameleon Domains Observed by Quantitative FRET Analysis and Polarized Fluorescence Correlation Spectroscopy [PDF]

, 2008
Förster resonance energy transfer (FRET) is a widely used method for monitoring interactions between or within biological macromolecules conjugated with suitable donor-acceptor pairs.
Laptenok, S., Visser, N.V., Kalinin, S., Hornen, H., Hoek, A., van, Kühnemuth, R., Borst, J.W., van Hoek, A., Westphal, A.H., Aker, J., Aker, J.C.M., Kyhnemuth, R., Laptenok, S.P., Seidel, C.A.M., Visser, A.J.W.G.   +14 more
core   +1 more source

Structural Flexibility Effect on Spaceborne Solar Observation System’s Micro-Vibration Response

Aerospace
The spaceborne solar observation system is crucial for the study of space phenomena such as solar flares, which requires high tracking accuracy.
Lin Yang, Yansong Wang, Lei Wei, Yao Chen   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Biological Implications of the Intrinsic Deformability of Human Acetylcholinesterase Induced by Diverse Compounds: A Computational Study

Biology
The enzyme acetylcholinesterase (AChE) plays a crucial role in the termination of nerve impulses by hydrolyzing the neurotransmitter acetylcholine (ACh).
Ysaías J. Alvarado, Lenin González-Paz, José L. Paz, Marcos A. Loroño-González, Julio Santiago Contreras, Carla Lossada, Alejandro Vivas, Yovani Marrero-Ponce, Felix Martinez-Rios, Patricia Rodriguez-Lugo, Yanpiero Balladores, Joan Vera-Villalobos   +11 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Agility and flexibility: what's the difference? [PDF]

, 1996
There is growing interest in the concept of “agile organisations” amongst management practitioners and academics. Early publications have been largely practitioner-oriented and have been at pains to claim that this is a new idea, with fundamental ...
Baker, John
core   +6 more sources