Results 31 to 40 of about 809,383 (310)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Apstract: Applied Studies in Agribusiness and Commerce, 2017 What impact has the Brexit on the allocation of money from the structural funds? As the UK is a net contributor to the EU budget, the budget for Structural and Cohesion Policy will shrink.
Wim Heijman
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
ROMANIAN ADMINISTRATIVE CAPACITY OF EUROPEAN FUNDS ABSOBTION [PDF]
CES Working Papers, 2011 The capacity to absorb European funds is part of a state complex integrated admninistrative capacity, a component of a state as a whole. The analysis in this article starts from the theoretical development by studying the reports made by the Romanian ...
Irina Bosie (Ungureanu), Andrei Puica
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ANALYSIS OF THE ABSORPTION OF EUROPEAN STRUCTURAL AND INVESTMENT FUNDS IN THE NEW MEMBER STATES OF CENTRAL AND EASTERN EUROPE [PDF]
Annals of the University of Oradea: Economic ScienceThe present research aims to analyze the impact of the allocation of structural and investment funds on regional development in the new member states of Central and Eastern Europe and to identify pragmatic ways to improve absorption, useful in the ...
Bogdan Cosmin MOLDOVAN
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
National Development Plans and Pre-accession Structural Funds: Learning from the Experiences of Ireland [PDF]
Romanian Journal of European Affairs, 2002 As it moves towards the new millennium, the Irish economy is impressive not only because of the extent/speed of the transformation and of its growth performance but also due to the fascinating effectiveness in implementing the Structural Funds programmes.
John Bradley
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
CONSIDERATIONS ABOUT ABSORPTION OF EUROPEAN FUNDS IN ROMANIA [PDF]
Annals of the University of Petrosani: Economics, 2019 The paper is structured in three chapters, first consisting of general information regarding the type of structural fund and their thematic objectives.
EDUARD EDELHAUSER
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