Results 141 to 150 of about 219,271 (347)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Ireland: An Example Of Best Practices In The Utilization of EU funds [PDF]
Ireland holds the story of a successful evolution from the moment of its accession to the European Union up to the present day, achieving an impressive economic transformation that repositioned the country in the hierarchy of developed EU member states ...
Amalia Nicoleta Coman, Paul Coman
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
E-Cohesion – a Simplification Method within European Union Rules
EIRP Proceedings, 2015 The e-cohesion is according to European Commission (EC) a set of common rules for simplifying the accountancy and more precise reporting for European structural funds and European investment funds by using the digital technologies and public databases ...
Paul Zai, Cristina Nicoleta Caranica
doaj
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Macro-regional evaluation of the Structural Funds using the HERMIN modelling framework. ESRI WP152(?). September 2003 [PDF]
, 2003 The structural fund interventions play a crucial role in improving the social and economic cohesion of the EU. A particular focus of the structural funds is on Objective 1 regions that lag behind to the extent that their GDP per capita is below 75 per ...
Bradley, John +2 more
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Croatian Accession to the European Union: Facing the Challenges of Negotiations [PDF]
This paper analyses the characteristics of EU regional policy and emphasizes the component of regional policy towards the Central and East European countries (CEEC) in the phases of candidacy and their full membership. Special importance was given to the
Ines Kersan-Skabic, Katarina Ott
core
Macro-regional evaluation of the Structural Funds using the HERMIN modelling framework [PDF]
, 2003 The structural fund interventions play a crucial role in improving the social and economic cohesion of the EU. A particular focus of the structural funds is on those regions that lag behind to the extent that their GDP per capita is below 75 per cent of ...
Bradley, John +2 more
core