Results 81 to 90 of about 5,350,927 (317)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The Structure of Neurovascular Innovations [PDF]
Stroke: Vascular and Interventional Neurology, 2021 openaire +4 more sources
Structural Change, Innovation and Growth in the Single EU Market [PDF]
An analysis of structural change along its main dimensions (relative goods and factor prices, shifts in sectoral output and employment shares, and the respective contributions of process and product innovation) is first presented.
Paul J.J. Welfens, Dora Borbély
core
Economic crisis and innovation: is destruction prevailing over accumulation? [PDF]
, 2012 The 2008 economic crisis has severely reduced the short-term willingness of firms to invest in innovation. But this reduction has not occurred uniformly and a few firms even increased their investment in spite of the adverse macroeconomic environment ...
Frenz, Marion +2 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Innovation and entrepreneurship: structural determinants of competitiveness [PDF]
Innovation and entrepreneurship have become the cornerstone of growth and competitiveness policies. They are both multidimensional, and thus highly complex, concepts.
B. Robert
core
National Biofilms Innovation Centre Annual Report 2025
, 2001 The National Biofilms Innovation Centre (NBIC) Annual Report 2025 covers key achievements to date and future ...
National Biofilms Innovation Centre,
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Functional characterization of human equilibrative nucleoside transporter 1
Protein & Cell, 2016 Equilibrative nucleoside transporters (ENTs), which facilitate cross-membrane transport of nucleosides and nucleoside-derived drugs, play an important role in the salvage pathways of nucleotide synthesis, cancer chemotherapy, and treatment for virus ...
Weiyun Huang +3 more
doaj +1 more source
Disentangling the Innovation - Internalization Process Through a Structural Equation Model [PDF]
Innovation virtuously impacts on the degree of international growth, which in turn positively influences innovation activities and then firms�™ performance (Filipescu et al., 2009).
Maurizio Carpita +2 more
core