Results 61 to 70 of about 5,350,927 (317)

Exit Statement : 2001-2009 CRC for Construction Innovation [PDF]

, 2009
The Cooperative Research Centre (CRC) for Construction Innovation is Australia’s national centre for research and innovation focused on the needs of the property, design, construction and facility management sectors. The period covered by this report is

core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

On the simultaneity of innovations and market structure [PDF]

Empirical Economics, 1992
This paper examines the determinants of innovations and market structure within a simultaneous framework. From a competitive fringe model, quasi-conditional factor demand functions are derived that explain product and process innovations in terms of factor prices and market structure variables such as relative firm size, market size, and the ...
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Structural basis of α1A-adrenergic receptor activation and recognition by an extracellular nanobody

Nature Communications, 2023
The α1A-adrenergic receptor (α1AAR) belongs to the family of G protein-coupled receptors that respond to adrenaline and noradrenaline. α1AAR is involved in smooth muscle contraction and cognitive function.
Yosuke Toyoda, Angqi Zhu, Fang Kong, Sisi Shan, Jiawei Zhao, Nan Wang, Xiaoou Sun, Linqi Zhang, Chuangye Yan, Brian K. Kobilka, Xiangyu Liu   +10 more
doaj   +1 more source

How institutional logics hamper innovation: The case of animal testing [PDF]

, 2017
For radical innovation to become successful the substitution of established practices are essential. Nevertheless, in the innovation literature novelty is often at the center and only little attention is paid to the influence of established technologies ...
Hekkert, M.P., Schellekens, H., Sub Biotechnological drugs, Innovation and Sustainability, Sub Drug delivery, Kooijman, M., van Meer, P.J.K., Moors, E.H.M., Innovation Studies, Dynamics of Innovation Systems   +9 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Mechanical and Thermal Performance Characterisation of Compressed Earth Blocks

Energies, 2020
The present research is focused on an experimental investigation to evaluate the mechanical, durability, and thermal performance of compressed earth blocks (CEBs) produced in Portugal.
Elisabete R. Teixeira, Gilberto Machado, Adilson de P. Junior, Christiane Guarnier, Jorge Fernandes, Sandra M. Silva, Ricardo Mateus   +6 more
doaj   +1 more source

Structural engineering of graphene for high‐resolution cryo‐electron microscopy

SmartMat, 2021
The revolutionary improvement of hardware and algorithm in cryogenic electron microscopy (cryo‐EM) has made it a routine method to obtain structures of macromolecules at near‐atomic resolution.
Jie Xu, Xiaoya Cui, Nan Liu, Yanan Chen, Hong‐Wei Wang   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source