Results 41 to 50 of about 18,298,166 (257)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Scale model of Sainte-Chapelle
, 1947 Model, detail on the north wall, originally the staircase (the Grands Degres); The Galerie des Moulages (cast collection) not only contains 19th plaster casts, but also scale models of buildings done by artisans on staff at the museum.
unknown (French model maker)
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Paris on Stage: 1889-1914 [exhibition]; Cabaret de L’Enfer Model
, 2016 Model of the facade of L'Enfer (Hell); Le Ciel (Heaven) is not shown, it was to the immediate left; A scale model, part of the Paris on Stage: 1889-1914 exhibition held June 19, 2013 to February 23, 2014.
unknown (Canadian model maker)
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Physical Review Letters, 2012 Predictions are developed for gradients and profiles of the electron density and temperature in tokamak H-mode pedestals that are in transport quasiequilibrium. They are based on assuming paleoclassical processes provide the irreducible minimum radial plasma transport and dominate in the steep gradient regions of pedestals.
J D, Callen, J M, Canik, S P, Smith
openaire +3 more sources
The 2010 fib Model Code for Structural Concrete: a new approach to structural engineering
, 2011 The fib Model Code is a recommendation for the design of reinforced and prestressed concrete which is intended to be a guiding document for future codes. Model Codes have been published before, in 1978 and 1990.
Bigaj-van Vliet, A., Walraven, J.C.
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source