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Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

A highly sensitive protein-RNA cross-linking mass spectrometry workflow with enhanced structural modeling potential. [PDF]

open access: yesNucleic Acids Res
Sarnowski CP   +8 more
europepmc   +1 more source
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