Results 171 to 180 of about 690,575 (314)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Combining structural modeling and deep learning to calculate the E. coli protein interactome and functional networks. [PDF]

Nat Commun
Zhao H, Velez C, Naravane A, Saha A, Feldman J, Skolnick J, Murray D, Honig B.   +7 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

HEMOS-Cloud: HPC Cloud-based Modeling and Simulation Platform for HEMOS Software

, 2017
Modeling & Simulation (M&S) is a technology that replaces the physical productionand experimentation of products with virtual production (modeling) and engineeringanalysis (simulation).
김명일, 김재성, 서동우, 정대용   +3 more
core  

Computational paradigms for antimicrobial resistance prediction: integrating multi-omics, structural modeling, and foundation artificial intelligence systems. [PDF]

Brief Bioinform
Hossain E, Yousefi N.
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Clinical characterization and structural modeling of a novel de novo SPTBN1 missense variant in a Chinese child. [PDF]

BMC Pediatr
Wang J, Zhang Y, Yang S, Xiao J, Yan H, Wang J.   +5 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Component-based structural equation modelling [PDF]

In this research, the authors explore the use of ULS-SEM (Structural-Equation-Modelling), PLS (Partial Least Squares), GSCA (Generalized Structured Component Analysis), path analysis on block principal components and path analysis on block scales on ...
TENENHAUS, Michel
core  

Integrative Machine Learning and Structural Modeling Identify Multitarget Therapeutic Candidates for Idiopathic Pulmonary Fibrosis. [PDF]

ACS Omega
Ding R, Zhang Y.
europepmc   +1 more source