Results 161 to 170 of about 502,417 (218)

Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mapping. [PDF]

Nat Commun
De Magalhaes Pinheiro I, Dawson JRD, Calo N, Paolini-Bertrand M, Akondi KB, Tan G, Handel TM, Kufareva I, Hartley O.   +8 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Multiscale Structural Elucidation of Vitrinite and Inertinite in Tar-High Coal: A Combined Characterization via FTIR, ¹³C NMR, XRD, XPS, Raman Spectroscopy, and Structural Modeling. [PDF]

ACS Omega
Lei L, Fan J, Meili D, Zhang J, Li J, Liu M, Lu Y, Zhang Y.   +7 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

MAST Kinases' Function and Regulation: Insights from Structural Modeling and Disease Mutations. [PDF]

Biomedicines
Lemke MC, Avala NR, Rader MT, Hargett SR, Lank DS, Seltzer BD, Harris TE.   +6 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

CIAA: Integrated Proteomics and Structural Modeling for Understanding Cysteine Reactivity with Iodoacetamide Alkyne. [PDF]

ACS Chem Biol
Boatner LM, Eberhardt J, Shikwana F, Holcomb M, Lee P, Houk KN, Forli S, Backus KM.   +7 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Food Allergy Knowledge, Attitudes, and Practices Among Restaurant's Staff in Bangladesh: A Structural Modeling Approach. [PDF]

Food Sci Nutr
Roy N, Imran SM, Debnath SC, Adib AA, Sultana S, Mahmud S, Rashid R, Hossain E, Islam F, Biswas KK.   +9 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source