Results 71 to 80 of about 690,575 (314)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A structural equation modeling analysis on solvency, operation and profitability of life insurers [PDF]

, 2013
textThe abilities of life insurers can be divided and measured from various aspects. Through the use of structural equation modeling, we investigate the relations among solvency, operation ability and profitability in year 1994, 1995 and 1996.
Zhu, Shuangshuang
core  

Instrumental Variables Two-Stage Least Squares (2SLS) vs. Maximum Likelihood Structural Equation Modeling of Causal Effects in Linear Regression Models

, 2019
In the presence of omitted variables or similar validity threats, regression estimates are biased. Unbiased estimates (the causal effects) can be obtained in large samples by fitting instead the Instrumental Variables Regression (IVR) model.
Shi, Dexin, Rosseel, Yves, Maydeu-Olivares, Alberto, Rosseel, YvesPP018010009749090000-0002-4129-4477F4D626CE-F0ED-11E1-A9DE-61C894A0A6B4   +3 more
core   +1 more source

Numerical modeling of stainless steel structural components - a consistent approach [PDF]

, 2004
This paper describes numerical modeling of the structural response of stainless steel hollow sections. The aim of the investigation was to develop a consistent approach to the modeling of stainless steel structures.
Gardner, L, Nethercot, DA
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A Marginal Maximum Likelihood Approach for Extended Quadratic Structural Equation Modeling with Ordinal Data

, 2020
The literature on non-linear structural equation modeling is plentiful. Despite this fact, few studies consider interactions between exogenous and endogenous latent variables.
Yang Wallentin, Fan, Jin, Shaobo, Vegelius, Johan   +2 more
core   +1 more source

Structural Model of Channelrhodopsin [PDF]

Journal of Biological Chemistry, 2012
Channelrhodopsins (ChRs) are light-gated cation channels that mediate ion transport across membranes in microalgae (vectorial catalysis). ChRs are now widely used for the analysis of neural networks in tissues and living animals with light (optogenetics).
Watanabe, H. C., Welke, K., Schneider, F., Tsunoda, S., Zhang, F., Deisseroth, K., Hegemann, P., Elstner, M.   +7 more
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Shaping a Safe Working Environment in the Coal Production Process: Utilizing Model Studies to Assess Methane Hazard Formation

Management Systems in Production Engineering
The establishment of a safe working environment is one of the key challenges in the implementation of various production processes. This is particularly relevant to underground coal production, where the primary operations (exploitation) take place in an
Tutak Magdalena, Brodny Jarosław, Romanyshyn Lyubomyr   +2 more
doaj   +1 more source