Results 241 to 250 of about 3,926,912 (305)

A two-week period of detraining reduces hippocampal volume in regularly active young adults: a structural MRI study. [PDF]

Behav Brain Funct
Cherednichenko A, Baena-Pérez M, Beltran-Valls MR, Moliner-Urdiales D, Ávila C.   +4 more
europepmc   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Newsletter (MRI News)

, 2009

core  

Brain structural MRI marker for predicting conversion to Parkinson's disease in individuals with prodromal symptoms. [PDF]

Front Aging Neurosci
Park CH, Yoon U, Lee PH, Kim J, Lee SK, Shin NY.   +5 more
europepmc   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

A radiomics model predicts progression from mild cognitive impairment to alzheimer's disease using structural MRI. [PDF]

Sci Rep
Li Y, Yi P, Jin M, Li Y, Chen W.
europepmc   +1 more source

Water‐Soluble Luminescent Trityl Radical for Fluorescence/Magnetic Resonance Dual‐Modal Imaging Probe

Advanced Science, EarlyView.
Stable water‐soluble luminescent tris(2,4,6‐trichlorophenyl)methyl (TTM) radicals, TTM‐trisTP3B and TTM‐trisTP9B, were designed and successfully synthesized. They exhibited deep‐red emissions and high photostability in water. TTM‐trisTP3B exhibited dual functionality as a fluorescence imaging (FI) probe and a magnetic resonance imaging (MRI) contrast ...
Kosuke Anraku, Satoshi Okada, Akira Sumiyoshi, Kenshiro Matsuda, Kazuhiro Nakamura, Takuya Hosokai, Ken Albrecht   +6 more
wiley   +1 more source

Altered Topology of Brain Structural Network in Patients With Migraine Without Aura: A Structural MRI Study. [PDF]

Eur J Pain
Cao ZM, Jia JN, Liu GY, Yang ZQ, Zhang JS, Shi AQ, Chen YC, Huo JW, Zhang YN, Liu N, Yan CQ, Wang J.   +11 more
europepmc   +1 more source

Longitudinal structural MRI-based deep learning and radiomics features for predicting Alzheimer's disease progression. [PDF]

Alzheimers Res Ther
Aghajanian S, Mohammadifard F, Mohammadi I, Rajai Firouzabadi S, Baradaran Bagheri A, Moases Ghaffary E, Mirmosayyeb O.   +6 more
europepmc   +1 more source

Multimodal phenotypic classification of generalized anxiety and panic using structural MRI data and psychosocial factors: machine learning results from the German National Cohort (NAKO) study. [PDF]

Transl Psychiatry
Gutzeit J, Weiß M, Kuhn T, Klinger-König J, Streit F, Jockwitz C, Brandes B, Wright MN, Friedrich CM, Woeckel M, Mikolajczyk R, Keil T, Castell S, Betker P, Schlett CL, Bärnighausen TW, Bamberg F, Günther M, Hirsch JG, Pischon T, Niendorf T, Leitzmann MF, Bohmann P, Wirkner K, Krist L, Wang Y, Berger K, Walther S, Grabe HJ, Deckert J, Caspers S, Hein G, Erhardt-Lehmann A.   +32 more
europepmc   +1 more source