Results 21 to 30 of about 5,411,731 (260)
Structural design optimization [PDF]
, 2007 Guest Editorial, Special Issue on Structural Design Optimization, Advances in Structural Engineering, An International Journal, 2007, Vol.
Liang, Qing Quan
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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MoleculesWe report a step-economic strategy for the direct synthesis of novel polycyclic N-heterocycle-fused naphthoquinones by merging intramolecular oxidative coupling and cascade [4 + 2] cycloaddition.
Yu Dong +9 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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Nano-Micro LettersHighlights The layered arrangement and gradient distribution of magnetic MXene are firstly combined to improve the electromagnetic wave (EMW) RL min and broaden effective absorption bandwidth.
Yang Zhou +9 more
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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Modeling, Analysis, and Optimization Under Uncertainties: a Review
, 2021 Design optimization of structural and multidisciplinary systems under uncertainty has been an active area of research due to its evident advantages over deterministic design optimization.
Ramu, Palaniappan +5 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
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Cut layout optimization for design of kirigami metamaterials under large stretching
Theoretical and Applied Mechanics LettersKirigami metamaterials have gained increasing attention due to their unusual mechanical properties under large stretching. However, most metamaterial designs obtained with trial-and-error approaches tend to lose their desirable properties under large ...
Chen Du, Yiqiang Wang, Zhan Kang
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
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