Results 71 to 80 of about 238,779 (294)

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

The Impact of Racism on Health: A Health Equity Training on Structural Racism for Military Residents and Fellows

MedEdPORTAL
Introduction Recognizing the need for more opportunities to learn about health equity within military graduate medical education (GME), we developed a resident-led curriculum to introduce these concepts from a military cultural competency lens.
Veronica Wright, Emily Stepp, Brittany Flemming, Courtney Kandler, Tirzah Wait, Loxley Godshall-Bennett, Rachel Robbins   +6 more
doaj   +1 more source

Leadership and Race: How to Develop and Support Leadership that Contributes to Racial Justice [PDF]

, 2010
This report explores the ways in which our current thinking about leadership often contributes to producing and maintaining racialized dynamics, and identifies a set of core competencies associated with racial justice leadership.
Deborah Meehan, Elissa Perry, Hanh Cao Yu, John A. Powell, Maggie Potapchuk, Sally Leiderman, Terry Keleher   +6 more
core  

Racism and anti-racism in Europe: a critical analysis of concepts and frameworks

, 2007
The targets and expressions of racism vary across Europe. This article discusses the relevance of different descriptions and analyses of racism despite the different terms used in different countries such as ‘ethnic minority’, ‘foreigner’ or ‘black’ and ...
Anthias, F., Anthias, F., Back, L., M. Keith, A. Khan, K. Shukra, Barker, M., Brubaker, W. R., CCCS (Centre for Contemporary Cultural Studies), Engbersen, G., Gilroy, P., Gilroy, P., Lamont, M., Lloyd, C., Miles, R., Nederven, P., Rath, J., Rex, J., Sivanandan, A., Soysal, Y., Ålund, A.   +17 more
core   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

The Consequences of Structural Racism, Concentrated Poverty, and Violence on Young Men and Boys of Color [PDF]

, 2011
Defining violence broadly as "systemic injury directed against a group or geographic area," this research brief describes the scope of violence that black young men and boys face as a result of structural conditions.
Carol Silverman, Mary Louise Frampton, Michael Sumner   +2 more
core  

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Disparities in Reproductive Aging and Midlife Health between Black and White women: The Study of Women’s Health Across the Nation (SWAN)

Women's Midlife Health, 2022
This paper reviews differences in the experience of the menopause transition and midlife health outcomes between Black and White women who participated in the Study of Women’s Health Across the Nation (SWAN), a 25-year, longitudinal, multi-racial/ethnic ...
Siobán D. Harlow, Sherri-Ann M. Burnett-Bowie, Gail A. Greendale, Nancy E. Avis, Alexis N. Reeves, Thomas R. Richards, Tené T. Lewis   +6 more
doaj   +1 more source

Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell–Mediated Repair Traumatic Brain Injury

Advanced Science, EarlyView.
This study presents a wireless, non‐invasive strategy for neural repair by developing a biodegradable piezoelectric dural patch that, under transcranial ultrasound, generates localized electrical fields to drive endogenous neural stem cells toward neuronal differentiation and functional integration.
Pengbo Zhou, Qingyuan Wu, Yang Wu, Runzhe Huang, Wei Li, Hanjie Niu, Hongtao Sun, Huiyu Liu   +7 more
wiley   +1 more source

Tiny Baby, Heavy Baby, Dark Baby [PDF]

, 2017
Tiny Baby, Heavy Baby, Dark Baby explores the construction of whiteness and the socialization of racial shame. Set in a grocery store, the fictional short story narrates a small moment between a toddler and her babysitter that has an immeasurable impact.
Yost-Wolff, Marlee
core   +1 more source