Results 111 to 120 of about 212,164 (259)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Structural Cement‐Based Supercapacitors with Multifunctional Robustness for Energy Storage

Advanced Science
The rapid deployment of renewable energy demands cost‐effective and scalable energy storage solutions. While cement‐based supercapacitors offer transformative potential, their development is hindered by charge storage capacity, mechanical strength, and ...
Qingyang Liu, Fengjuan Wang, Yu Zhang, Shuo Dong, Zhiyong Liu, Liguo Wang, Taotao Feng, Shiyu Sui, Yuncheng Wang, Jinyang Jiang, Peng Li   +10 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Imparting structural robustness of metal-organic cages based on oxo-dimolybdenum clusters.

Dalton Trans, 2023
Delaporte S, Abánades Lázaro I, López-Cabrelles J, Mazarakioti EC, Chebourou S, Vitórica-Yrezábal IJ, Giménez-Marqués M, Mínguez Espallargas G.   +7 more
europepmc   +1 more source

Reliability-Based Design Optimisation of Bridge Systems Within BIM—Robustness, Redundancy and Safety Metrics

Buildings
Research shows that structures are often over designed in reliability-based calculations compared to code requirements. To address the knowledge gap in applying Reliability Based Design Optimisation (RBDO) within Building Information Modelling (BIM ...
John Dixon, Van Bac Nguyen, Boris Ceranic   +2 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

B-Edge Differential Measures for Structural Robustness of Certain Graph Classes

Journal of Mathematics
The use of graph-theoretic parameters is essential in interpreting the structural robustness, efficiency, and functionality of complex networks. Specifically, edge-based metrics are more useful in interpreting the susceptibility of links and the concept ...
Hafiz Muhammad Afzal Siddiqui, Muhammad Usman, Syed Ajaz Kareem Kirmani, Michael Onyango Ojiema, Muhammad Yasir Hayat Malik   +4 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Achieving structural robustness

ce/papers
Abstract Robustness analyses aims at preventing a structural system from failing after the occurrence of damage, exceptional/unexpected events, or operational malfunctions. This paper reviews the key aspects of robustness in structures, and associated concepts such as redundancy and resilience.
Alfred Strauss, Andreas Pürgstaller, Patricio Quintana Gallo, Panagiotis Spyridis, Stefano Pampanin, Konrad Bergmeister   +5 more
openaire   +1 more source