Results 81 to 90 of about 212,164 (259)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Risk-Based Assessment of Structural Robustness

Bulletin of the Polytechnic Institute of Jassy: Constructions, Architechture Section, 2010
Providing safety of structures is one of the main aims of design. In traditional design it is achieved by designing structural components against specified limit states.
Oana-Mihaela Ioniţă, N. Ţăranu, Silvia Romînu, Cătălin Banu   +3 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Structural Features and Robustness of Coupled Software Networks

Transactions of Nanjing University of Aeronautics and Astronautics
Software systems play increasing important roles in modern society， and the ability against attacks is of great practical importance to crucial software systems， resulting in that the structure and robustness of software systems have attracted a ...
WANG Ershen, TONG Zeqi, HONG Chen, WANG Yanwen, MEI Sen, XU Song, NA La   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Understanding Failures, an Useful Tool in Structural Robustness Evaluation [PDF]

Bulletin of the Polytechnic Institute of Jassy: Constructions, Architechture Section, 2008
Learning from failures is a powerful educational tool for all civil and structural engineers. Although structural designers do not wish to discuss their shortcomings and mistakes from their activity a detailed analysis of failure cases is an instructive ...
Silvia Romînu, Oana-Mihaela Ioniţă, Nicolae Ţăranu, Radu Băncilă, Cătălin Banu   +4 more
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Robustness - Robust structures by joint ductility

, 2007
In view of recent disasters and their immense economical and human consequences more and more focus is given not only on the safety of structures - to reduce the risk for the life of people by collapse even under exceptional loading – but on minimizing the disastrous results and to enable a quick rebuilding and reuse.
Kuhlmann, Ulrike, Rölle, Lars, Jaspart, Jean-Pierre, Demonceau, Jean-François   +3 more
openaire   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source