Results 31 to 40 of about 473,953 (266)
MicromachinesThe precise isolation of circulating tumor cells (CTCs) from blood samples is a potent tool for cancer diagnosis and clinical prognosis. However, CTCs are present in extremely low quantities in the bloodstream, posing a significant challenge to their ...
Lin Lin +4 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Large strain nonlinear model of lead rubber bearings for beyond design basis earthquakes
Nuclear Engineering and Technology, 2019 Studies on the application of the lead rubber bearing (LRB) isolation system to nuclear power plants are being carried out as one of the measures to improve seismic performance.
Seunghyun Eem, Daegi Hahm
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Applied Sciences, 2021 Due to environmental pollution and depletion of fossil fuels, hydrogen is becoming an increasingly practical, clean and environmentally friendly option for transportation and energy storage among all green alternative energy sources introduced.
Sungwook Kang +7 more
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Spatial and temporal evolution of carbon stocks in Yulin City under changing environments
Scientific ReportsLand use changes directly or indirectly affect the regional carbon balance. Investigating the spatial and temporal evolution of regional carbon stock and the contribution of land use driving factors is crucial for understanding the formation mechanisms ...
Guikai Sun +3 more
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Performance of the Cold-Bending Channel-Angle Buckling-Restrained Brace under Cyclic Loading
Advances in Civil Engineering, 2019 In this study, three restricted cold-bending channel-angle buckling-restrained brace (CCA-BRB) specimens were experimentally characterised by a low-reversed cyclic loading test. Three specimens had steel cores with cruciform cross section.
Kun Wang +5 more
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
RiverOptimizing reservoir refill operation rules is crucial for enhancing reservoir sustainability and resilience. This study proposes a refill operation model designed to derive optimal refill guide curves by considering flood risk prevention, maximum ...
Lihua Chen +4 more
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