Results 41 to 50 of about 473,953 (266)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Structural Safety Generalization Problem
Findings of the Association for Computational Linguistics: ACL 2025LLM jailbreaks are a widespread safety challenge. Given this problem has not yet been tractable, we suggest targeting a key failure mechanism: the failure of safety to generalize across semantically equivalent inputs. We further focus the target by requiring desirable tractability properties of attacks to study: explainability, transferability between ...
Julius Broomfield +9 more
openaire +3 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Nuclear Engineering and TechnologyThis study evaluates the effects of chloride-induced deterioration of exterior reinforced concrete (RC) walls of a nuclear power plant. A multi-scale analytical framework was proposed, linking wall-level stiffness degradation, building-level elastic time-
Hyeon-Keun Yang +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Analysis of a micro piezoelectric vibration energy harvester by nonlocal elasticity theory
Advances in Mechanical Engineering, 2016 A theoretical model of a micro piezoelectric energy harvester is proposed based on the nonlocal elasticity theory, which is operated in the flexural mode for scavenging ambient vibration energy.
Hao Chen +3 more
doaj +1 more source
Mechanical Performance of Built-Up Columns Composed of Four Cold-Formed Square Steel Tubes
Applied Sciences, 2019 This study presents an experimental investigation into the mechanical performance of built-up columns composed of four cold-formed square steel tubes under axial load.
Xiaomiao Chen +3 more
doaj +1 more source
Effect of terahertz irradiation on DNA damage repair in living cells
FEBS Open Bio, EarlyView.We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno +3 more
wiley +1 more source
Advances in Civil Engineering, 2019 The true stress-strain curve is the critical method to describe the practical material mechanical performance and the essential precondition to develop the advanced numerical simulation.
Bo Xu +6 more
doaj +1 more source