Results 151 to 160 of about 5,976,633 (297)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Combining pairwise structural similarity and deep learning interface contact prediction to estimate protein complex model accuracy in CASP15. [PDF]

Proteins, 2023
Roy RS, Liu J, Giri N, Guo Z, Cheng J.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Inferring Local Protein Structural Similarity from Sequence Alone. [PDF]

J Chem Inf Model
Ma Z, Espinoza Herrera J, Buitrago-Delgado E, Bethel NP, Jinich A.   +4 more
europepmc   +1 more source

Detection of infrared small target based on background subtraction local contrast measure and Gaussian structural similarity. [PDF]

Heliyon, 2023
Zhu D, Tang J, Fu X, Geng Y, Su J.
europepmc   +1 more source

Structural similarity networks predict clinical outcome in early-phase psychosis

Neuropsychopharmacology, 2019
P. Homan, M. Argyelan, P. DeRosse, P. Szeszko, J. Gallego, Lauren Hanna, D. Robinson, J. Kane, T. Lencz, A. Malhotra   +9 more
semanticscholar   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Multi-scale structural similarity embedding search across entire proteomes. [PDF]

Bioinformatics
Segura J, Sanchez-Garcia R, Bittrich S, Rose Y, Burley SK, Duarte JM.   +5 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source