Results 161 to 170 of about 4,318,402 (294)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Inferring Local Protein Structural Similarity from Sequence Alone. [PDF]

J Chem Inf Model
Ma Z, Espinoza Herrera J, Buitrago-Delgado E, Bethel NP, Jinich A.   +4 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Combining pairwise structural similarity and deep learning interface contact prediction to estimate protein complex model accuracy in CASP15. [PDF]

Proteins, 2023
Roy RS, Liu J, Giri N, Guo Z, Cheng J.
europepmc   +1 more source

Similarity methods Proceedings

, 1998
Similarity, analogy, and symmetry are attractive concepts and modeling methods in many areas of the pure and applied sciences. In recent years attention has been brought to similarity methods again, mostly due to new theoretical work and new applications,
Kroeplin, B., Rudolph, S., Brueckner, S. (eds.), Stuttgart Univ. (Germany). Inst. fuer Statik und Dynamik der Luft- und Raumfahrtkonstruktionen   +3 more
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

MIND versus MSN: A systematic evaluation of test-retest reliability and age sensitivity for T1-weighted structural similarity networks. [PDF]

Netw Neurosci
Gao J, Hu Y.
europepmc   +1 more source

Integrated analysis of multimodal single-cell data with structural similarity. [PDF]

Nucleic Acids Res, 2022
Cao Y, Fu L, Wu J, Peng Q, Nie Q, Zhang J, Xie X.   +6 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Multi-scale structural similarity embedding search across entire proteomes. [PDF]

Bioinformatics
Segura J, Sanchez-Garcia R, Bittrich S, Rose Y, Burley SK, Duarte JM.   +5 more
europepmc   +1 more source