Results 141 to 150 of about 126,369 (255)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Subgingival microbiota composition is associated with brain health in the general population-the PAROMIND study. [PDF]

EBioMedicine
Petersen M, Walther C, Borof K, Heydecke G, Beikler T, Alawi M, Müller C, Nägele FL, Zyriax BC, Fiehler J, Gallinat J, Kühn S, Twerenbold R, Bang C, Thomalla G, Cheng B, Aarabi G.   +16 more
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Subjective and Objective Quality Assessment of Image: A Survey

Majlesi Journal of Electrical Engineering
With the increasing demand for image-based applications, the efficient and reliable evaluation of image quality has increased in importance. Measuring the image quality is of fundamental importance for numerous image processing applications, where the ...
Pedram Mohammadi, Abbas Ebrahimi-Moghadam, Shahram Shirani   +2 more
doaj  

Uncovering viral protein acquisition events and human-specific folds with pairwise comparisons of predicted protein structures. [PDF]

Mol Biol Evol
Malnak JC, Montermoso S, Bushman FD, Auslander N.   +3 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Isostructurality and energetics of competitive C-H⋯π interactions in adamantane-benzoate hybrids: a computational ADME study. [PDF]

RSC Adv
Pérez H.
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Image reconstruction from incomplete data via approximated pseudo-inverse and dual-domain coupled diffusion posterior sampling. [PDF]

Quant Imaging Med Surg
Xing Q, Zheng Z, Cai A, Wang C, Li L, Yan B.   +5 more
europepmc   +1 more source