Results 151 to 160 of about 1,015,002 (311)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

On the Myelin-Axon Interaction: Structural Studies of Myelin-Associated Glycoprotein, Olfactomedin-1 and the Nogo Receptor

, 2017
In most parts of the body, nerves regenerate after injury. However, in the brain and spinal cord regeneration is very limited. One of the causes for this lack of regeneration is the presence of myelin proteins that inhibit outgrowth of neuronal ...
Sub Crystal and Structural Chemistry, Crystal and Structural Chemistry, Pronker, M.F.   +2 more
core  

Structural Stability of AM/AMPS/AMB Terpolymers Under Simulated Extreme Oilfield Conditions. [PDF]

Polymers (Basel)
Xue P, Wang J, Fang J, Ma Q, Kang Z, Xi L, Dong X, Zhang Y, Yang Z, He L.   +9 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

The fire behaviour of extended stiffened joints designed for seismic actions

, 2019
The structural behaviour of steel moment resisting frames (MRFs) is strongly dependent on the beam-to-column joint behaviour. The role of the joints is crucial especially under accidental natural and human induced actions, as in the cases of earthquake ...
Landolfo Raffaele, Zimbru M., Wald F., LINGUITI, ALESSIA, Tartaglia Roberto, D'Aniello Mario   +5 more
core  

Elucidating the Solvent-Dependent Solvation and Structural Stability of Irinotecan: A Molecular Simulation Study. [PDF]

Chemphyschem
Bitabo MM, Mlowe S, Shadrack DM, Paluch AS, Paul L.   +4 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Financial Stability Report 2015 : vulnerabilities and risks

, 2015
In the annual Financial Stability Report, Norges Bank assesses vulnerabilities and risks in the financial system, with a focus on the long-term, structural features of banks, financial markets and the Norwegian economy that are of importance for ...

core  

Disease associated missense substitutions disrupt structural stability and catalytic function of 4-hydroxyphenylpyruvate dioxygenase. [PDF]

J Biol Chem
Huang CW, Ni MY, Huang WM, Huang HC, Hsu YC, Huang KL, Chen CH, Hwang CC, Chang YL, Lee HJ.   +9 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source