Results 21 to 30 of about 2,730,897 (264)

3D Interaction Homology: Computational Titration of Aspartic Acid, Glutamic Acid and Histidine Can Create pH-Tunable Hydropathic Environment Maps

Frontiers in Molecular Biosciences, 2021
Aspartic acid, glutamic acid and histidine are ionizable residues occupying various protein environments and perform many different functions in structures. Their roles are tied to their acid/base equilibria, solvent exposure, and backbone conformations.
Noah B. Herrington, Glen E. Kellogg, Glen E. Kellogg   +2 more
doaj   +1 more source

Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against SARS-CoV-2 Omicron variants

Cell Discovery, 2023
The pandemic of COVID-19 caused by SARS-CoV-2 continues to spread around the world. Mutant strains of SARS-CoV-2 are constantly emerging. At present, Omicron variants have become mainstream.
Xiangyang Chi, Lingyun Xia, Guanying Zhang, Ximin Chi, Bangdong Huang, Yuanyuan Zhang, Zhengshan Chen, Jin Han, Liushu Wu, Zeya Li, Hancong Sun, Ping Huang, Changming Yu, Wei Chen, Qiang Zhou   +14 more
doaj   +1 more source

Protocol for establishing a protein-protein interaction network using tandem affinity purification followed by mass spectrometry in mammalian cells

STAR Protocols, 2022
Summary: Identification of protein interactors is fundamental to understanding their functions. Here, we describe a modified protocol for tandem affinity purification coupled with mass spectrometry (TAP/MS), which includes two-step purification.
Weixiang Bian, Hua Jiang, Shan Feng, Junjie Chen, Wenqi Wang, Xu Li   +5 more
doaj   +1 more source

Structural Studies of the Sputnik Virophage [PDF]

Journal of Virology, 2010
ABSTRACT The virophage Sputnik is a satellite virus of the giant mimivirus and is the only satellite virus reported to date whose propagation adversely affects its host virus' production. Genome sequence analysis showed that Sputnik has genes related to viruses infecting all three domains of life. Here, we report structural studies of Sputnik,
Sun, S. Y., La Scola, B., Bowman, V. D., Ryan, C. M., Whitelegge, J. P., /Raoult, Didier, Rossmann, M. G.   +6 more
openaire   +3 more sources

Systematized analysis of secondary structure dependence of key structural features of residues in soluble and membrane-bound proteins

Journal of Structural Biology: X, 2021
Knowledge of three-dimensional protein structure is integral to most modern drug discovery efforts. Recent advancements have highlighted new techniques for 3D protein structure determination and, where structural data cannot be collected experimentally ...
Mohammed H. AL Mughram, Noah B. Herrington, Claudio Catalano, Glen E. Kellogg   +3 more
doaj   +1 more source

Structural studies on lens proteins [PDF]

Biochemical Journal, 1967
The sequence around the thiol group in lens proteins has been investigated. The proteins were converted into their carboxy[(14)C]methyl derivatives and submitted to partial acid hydrolysis, or digested with proteolytic enzymes. Acid hydrolysis of bovine alpha-crystallin gives N-seryl-(S-carboxymethyl)cysteine, Ser-CMCys (Waley, 1965a), but this ...
C C, Mok, S G, Waley
openaire   +2 more sources

Synthesis and Characterization of SnO₂/α-Fe₂O₃, In₂O₃/α-Fe₂O₃, and ZnO/α-Fe₂O₃ Thin Films: Photocatalytic and Antibacterial Applications

Surfaces
The fabrication of metal oxide semiconductor heterostructures is a major way to enhance their properties in photocatalytic and antibacterial applications.
Asma Arfaoui, Ammar Mhamdi
doaj   +1 more source

Neuroprotection and immunomodulation following intraspinal axotomy of motoneurons by treatment with adult mesenchymal stem cells

Journal of Neuroinflammation, 2018
Background Treatment of spinal cord injury is dependent on neuronal survival, appropriate synaptic circuit preservation, and inflammatory environment management. In this sense, mesenchymal stem cell (MSC) therapy is a promising tool that can reduce glial
A. B. Spejo, G. B. Chiarotto, A. D. F. Ferreira, D. A. Gomes, R. S. Ferreira, B. Barraviera, A. L. R. Oliveira   +6 more
doaj   +1 more source

Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods

Frontiers in Molecular Biosciences, 2021
The inherent flexibility of intrinsically disordered proteins (IDPs) makes it difficult to interpret experimental data using structural models. On the other hand, molecular dynamics simulations of IDPs often suffer from force-field inaccuracies, and long
Mustapha Carab Ahmed, Line K. Skaanning, Alexander Jussupow, Estella A. Newcombe, Estella A. Newcombe, Birthe B. Kragelund, Carlo Camilloni, Carlo Camilloni, Annette E. Langkilde, Kresten Lindorff-Larsen   +9 more
doaj   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source