Results 61 to 70 of about 2,730,897 (264)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Embryonic stem cells overexpressing high molecular weight FGF2 isoform enhance recovery of pre-ganglionic spinal root lesion in combination with fibrin biopolymer mediated root repair

Stem Cell Research & Therapy
Background Spinal ventral root avulsion results in massive motoneuron degeneration with poor prognosis and high costs. In this study, we compared different isoforms of basic fibroblast growth factor 2 (FGF2), overexpressed in stably transfected Human ...
B. H. M. Lima, L. P. Cartarozzi, S. Kyrylenko, R. S. Ferreira, B. Barraviera, Alexandre L. R. Oliveira   +5 more
doaj   +1 more source

Probabilistic Reliability Assessment of Truss Construction in Matlab Software Platform

Transactions of the VŠB: Technical University of Ostrava, Civil Engineering Series, 2014
This paper deals with the use of probabilistic methods in assessing the reliability of the planar truss support structure. Classical Monte Carlo simulation technique was chosen for calculation of failure probability in structural elements and the entire ...
Vašek Jakub, Krejsa Martin
doaj   +1 more source

Computational Characteristics of the Striatal Dopamine System Described by Reinforcement Learning With Fast Generalization

Frontiers in Computational Neuroscience, 2020
Generalization is the ability to apply past experience to similar but non-identical situations. It not only affects stimulus-outcome relationships, as observed in conditioning experiments, but may also be essential for adaptive behaviors, which involve ...
Yoshihisa Fujita, Sho Yagishita, Sho Yagishita, Haruo Kasai, Haruo Kasai, Shin Ishii, Shin Ishii, Shin Ishii   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Genomic basis of adaptation to cardiac glycosides in three insect orders

Frontiers in Genetics
Insects across different orders have convergently evolved adaptations to toxic cardiac glycosides (CGs), which are derived either from their diet or via endogenous synthesis. Previous studies on CG-resistance focused on changes in ATPα that is the direct
Kangli Zhu, Kangli Zhu, Kangli Zhu, Chengqi Zhu, Ying Zhen, Ying Zhen, Ying Zhen   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Exploratory Pharmacokinetic Characterization of Enrofloxacin and Ciprofloxacin in Plasma and Interstitial Fluid of Dogs: Nonlinear Mixed-Effects Modeling and PK/PD Target Attainment Analysis

Antibiotics
Background: Assessment of antimicrobial exposure at the site of infection is essential for pharmacokinetic/pharmacodynamic (PK/PD)-guided antimicrobial therapy, yet plasma concentrations may not adequately reflect extracellular target-site exposure. This
Patrik Mag, Zoltán Somogyi, Andrea Kertenics, Márton Kovács, Pál Szabó, Ákos Jerzsele   +5 more
doaj   +1 more source