FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Structural Embedding of Oral Health Within Pooled Universal Coverage Mechanisms: Where Are We in 2026? [PDF]
Healthcare (Basel)Moussa C +5 more
europepmc +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
An Approach for Decentralized Mode Estimation Based on the Random Decrement Method
Shock and Vibration, 2010 A. Friedmann, D. Mayer, M. Kauba
doaj +1 more source
A GIS-based AHP approach integrating geospatial and magnetic data for groundwater potential mapping in a structurally complex arid region, Egypt. [PDF]
Sci RepZamzam S +3 more
europepmc +1 more source
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source
Haken-Entropy-Based Analysis of the Synergy Among Financial Support, Technological Innovation, and Industrial Upgrading. [PDF]
Entropy (Basel)Zhang Y, Ke J, He J.
europepmc +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Low-field strain-driven phase diagram of (Bi<sub>1/2</sub>Na<sub>1/2</sub>)TiO<sub>3</sub>-SrTiO<sub>3</sub>-LiNbO<sub>3</sub> lead-free relaxor ceramics for actuator applications. [PDF]
RSC AdvThien Khoi NH, Thang NH.
europepmc +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source