Results 81 to 90 of about 3,247,721 (357)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Atomistic modeling of amorphous silicon carbide: An approximate first-principles study in constrained solution space [PDF]
, 2009 Localized basis ab initio molecular dynamics simulation within the density functional framework has been used to generate realistic configurations of amorphous silicon carbide (a-SiC).
Elliot S R +15 more
core +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Structural design studies of a supersonic cruise arrow wing configuration [PDF]
Structural member cross sections were sized with a system of integrated computer programs to satisfy strength and flutter design requirements for several variants of the arrow wing supersonic cruise vehicle.
Beskenis, S. D. +5 more
core +1 more source
Creep fatigue life prediction for engine hot section materials (isotropic): Two year update [PDF]
, 1984 Requirements for increased durability of gas turbine hot section components have placed a greater degree of importance on accurate structural analysis and life prediction.
Moreno, V.
core +1 more source
Anomalous structural and mechanical properties of solids confined in quasi one dimensional strips [PDF]
, 2008 We show using computer simulations and mean field theory that a system of particles in two dimensions, when confined laterally by a pair of parallel hard walls within a quasi one dimensional channel, possesses several anomalous structural and mechanical ...
Chaudhuri D. +4 more
core +2 more sources
A bar and hinge model formulation for structural analysis of curved-crease origami
International Journal of Solids and Structures, 2020 In this paper, we present a method for simulating the structural properties of curved-crease origami through the use of a simplified numerical method called the bar and hinge model.
Steven R. Woodruff, E. Filipov
semanticscholar +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Oriental Studies, 2018 The article is dedicated to the system description and structural-semantic analysis of the spatial postpositions revealed on material of the Kalmyk khans' letters language of the XVIIIth century.
Evgeniy Vladimirovich Bembeev +1 more
doaj +1 more source